{"id":"W2513909258","doi":"10.1182/blood.v106.11.5011.5011","title":"The Role of Proteasome Inhibitors and the Trail Apoptotic Pathway in the Treatment of Chronic Lymphocytic Leukemia.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chronic lymphocytic leukemia; Apoptosis; Proteasome; Proteasome inhibitor; Cancer research; Cytotoxic T cell; Monoclonal antibody; Programmed cell death; Leukemia; Cancer cell; Chlorambucil; Multiple myeloma; Biology; Antibody; Immunology; Cancer; Cell biology; Biochemistry; In vitro; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004724888,0.0003356575,0.0003121572,0.0004456842,0.0001984234,0.0003718309,0.0001750497,0.0002799151,0.0006189072],"category_scores_gemma":[0.0001675334,0.0001002361,0.0002702232,0.0002663384,0.0002063461,0.0002505438,0.0001817784,0.0004006989,0.0001643045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005504474,"about_ca_system_score_gemma":0.0004096036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006871576,"about_ca_topic_score_gemma":0.001821689,"domain_scores_codex":[0.9998286,0.00004836422,0.00002352646,0.00001753264,0.00004392062,0.00003819119],"domain_scores_gemma":[0.9998966,0.00001699084,0.00003920019,0.000005970959,0.0000158678,0.00002526081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008938902,0.001030307,0.005115062,0.001600004,0.0002222389,0.001047658,0.000107385,0.001391297,0.4980431,0.001311517,0.002922376,0.4782702],"study_design_scores_gemma":[0.006231085,0.03253408,0.0693915,0.0004719918,0.0008175798,0.0111855,0.0001766672,0.006126229,0.63276,0.001396431,0.2388227,0.00008624093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5469764,0.4413665,0.002538084,0.001493495,0.0003933055,0.0001832995,0.000302248,0.0001166601,0.006629981],"genre_scores_gemma":[0.9377198,0.05696216,0.001956061,0.0003295676,0.0001907043,0.00009260068,0.0003111655,0.00001176933,0.002426176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006871576,"threshold_uncertainty_score":0.003993809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003600923299990195,"score_gpt":0.1969515338028518,"score_spread":0.1933506105028616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}