{"id":"W2514057855","doi":"10.1139/cjc-2016-0307","title":"Guanidine-catalyzed asymmetric Strecker reaction: modes of activation and origin of stereoselectivity","year":2016,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National University of Singapore","keywords":"Chemistry; Bifunctional; Transition state; Imine; Non-covalent interactions; Catalysis; Aryl; Guanidine; Lewis acids and bases; Hydrogen bond; Strecker amino acid synthesis; Brønsted–Lowry acid–base theory; Medicinal chemistry; Stereochemistry; Computational chemistry; Enantioselective synthesis; Organic chemistry; Molecule","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002296083,0.0001346434,0.000363722,0.0002207319,0.0000383777,0.00001208966,0.0001915457,0.0001449868,0.0002596229],"category_scores_gemma":[0.0006832776,0.0001040807,0.0001312984,0.0004478202,0.0001104934,0.0002072896,0.00001175648,0.0001275749,8.06986e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002054918,"about_ca_system_score_gemma":0.0006092317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007130905,"about_ca_topic_score_gemma":0.0001002875,"domain_scores_codex":[0.9989628,0.00001189319,0.0004703916,0.0001455772,0.0002292015,0.0001800905],"domain_scores_gemma":[0.9982083,0.0002295004,0.0007024044,0.000229899,0.0003302433,0.0002996964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003925805,0.00002790113,0.02008906,0.0001260749,0.0001473205,0.000005013675,0.00004283596,0.00000120878,0.9258918,0.00001293568,0.0002224531,0.05339411],"study_design_scores_gemma":[0.0004844335,0.00000924602,0.002411084,0.0001935439,0.00006808994,0.00005240031,0.0002394633,0.000009060544,0.995541,0.00007300296,0.0008067064,0.0001119193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98711,0.0003804652,0.000262756,0.0001242206,0.00002026817,0.00001528014,0.00006065922,0.000003306067,0.01202304],"genre_scores_gemma":[0.999157,0.00006462077,0.0001159722,0.000003376715,0.0001265103,0.000001060599,0.000004745975,0.00001448715,0.0005123001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06964923,"threshold_uncertainty_score":0.4244286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01544839182002041,"score_gpt":0.2171279518621289,"score_spread":0.2016795600421084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}