{"id":"W2514078591","doi":"10.1021/acs.joc.6b01593","title":"Enhanced Glutathione Peroxidase Activity of Water-Soluble and Polyethylene Glycol-Supported Selenides, Related Spirodioxyselenuranes, and Pincer Selenuranes","year":2016,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Organoselenium and organotellurium chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Asociación de Amigos de la Universidad de Navarra; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Technology Futures; Alberta Innovates - Health Solutions; Trinity College Dublin; Universidad de Navarra","keywords":"Chemistry; Hydrogen peroxide; Polyethylene glycol; PEG ratio; Antioxidant; Pincer movement; Aqueous solution; Diselenide; Solubility; Organic chemistry; Catalysis; Selenide; Glutathione; Combinatorial chemistry; Nuclear chemistry; Polymer chemistry; Selenium; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308659,0.0003883287,0.0001583079,0.0001361295,0.00004298698,0.0001299031,0.0001578746,0.0001738205,0.000474845],"category_scores_gemma":[0.0001248092,0.0001019098,0.0001453331,0.0001367147,0.0001177947,0.0001845029,0.0001438781,0.0002330027,0.000160335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064505,"about_ca_system_score_gemma":0.0000884434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001249103,"about_ca_topic_score_gemma":0.0002503478,"domain_scores_codex":[0.9999311,0.00001421326,0.00000767352,0.0000149626,0.00001540703,0.00001677401],"domain_scores_gemma":[0.999954,0.000006551827,0.00001508265,0.000004148675,0.000008549384,0.00001158004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005774012,0.00001193097,0.00004480859,0.00002159796,0.000003839733,0.00001949429,0.00001159097,0.00005175747,0.9988225,0.0000454835,0.00001047188,0.0008986941],"study_design_scores_gemma":[0.000005107403,0.0002246511,0.0002615933,0.000001355169,0.000005949537,0.0000250488,0.000007854445,0.000177585,0.9988742,0.000009874905,0.0004048666,0.000001828173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997722,0.0006316883,0.001097975,0.00001972316,0.000007709777,0.00000947845,0.00005135317,0.00002417111,0.000435953],"genre_scores_gemma":[0.9963426,0.0006422446,0.001480408,0.00001230921,0.000003938213,0.00001084301,0.0001513759,0.000007703305,0.001348588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000474845,"threshold_uncertainty_score":0.001588523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02108769468439787,"score_gpt":0.3055145920155038,"score_spread":0.2844268973311059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}