{"id":"W2514078591","doi":"10.1021/acs.joc.6b01593","title":"Enhanced Glutathione Peroxidase Activity of Water-Soluble and Polyethylene Glycol-Supported Selenides, Related Spirodioxyselenuranes, and Pincer Selenuranes","year":2016,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Organoselenium and organotellurium chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Asociación de Amigos de la Universidad de Navarra; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Technology Futures; Alberta Innovates - Health Solutions; Trinity College Dublin; Universidad de Navarra","keywords":"Chemistry; Hydrogen peroxide; Polyethylene glycol; PEG ratio; Antioxidant; Pincer movement; Aqueous solution; Diselenide; Solubility; Organic chemistry; Catalysis; Selenide; Glutathione; Combinatorial chemistry; Nuclear chemistry; Polymer chemistry; Selenium; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001027094,0.0003569408,0.000584854,0.0000442089,0.0002117052,0.000014979,0.0003859635,0.0005197008,0.003881742],"category_scores_gemma":[0.0001675957,0.0002027378,0.0001020979,0.0001832549,0.0006504636,0.0002118966,0.0001656177,0.0008430207,0.00001387773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009196411,"about_ca_system_score_gemma":0.0002342502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006891911,"about_ca_topic_score_gemma":0.000001960595,"domain_scores_codex":[0.9979927,0.000214879,0.0007546765,0.0002736207,0.0002903719,0.0004737866],"domain_scores_gemma":[0.9979721,0.0005165838,0.0006335553,0.0003006668,0.0002577961,0.0003193232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001098015,0.0002259838,0.000694118,0.0003288798,0.000355674,0.00002854322,0.001237325,0.000001486953,0.9932075,8.629362e-7,0.0001997606,0.002621923],"study_design_scores_gemma":[0.003654403,0.0001359052,0.001055869,0.0001117399,0.0005722228,0.001806026,0.0002009301,0.000006516653,0.9914105,0.00009558455,0.0006687322,0.0002815575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945791,0.002439362,0.00005617619,0.002332293,0.0002470877,0.0001363558,0.00002438882,0.0000366645,0.000148583],"genre_scores_gemma":[0.9930258,0.005066729,0.00003762815,0.0000725373,0.000261464,0.000001655961,0.000003140737,0.00004773662,0.001483293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003867864,"threshold_uncertainty_score":0.9970288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02108769468439787,"score_gpt":0.3055145920155038,"score_spread":0.2844268973311059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}