{"id":"W2514125340","doi":"10.1038/nature19424","title":"Designing the ideal opioid","year":2016,"lang":"en","type":"letter","venue":"Nature","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Opioid; Opium; Opioid receptor; Morphine; Pharmacology; Agonist; Drug discovery; Receptor; Medicine; Chemistry; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001613975,0.0003203615,0.0005099514,0.000277137,0.001233183,0.001878788,0.001027015,0.004886057,0.005641663],"category_scores_gemma":[0.002587011,0.0003502764,0.0004108245,0.0001460445,0.00272495,0.003009967,0.001403,0.007454502,0.00305196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001384964,"about_ca_system_score_gemma":0.001551811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004770053,"about_ca_topic_score_gemma":0.001388078,"domain_scores_codex":[0.999391,0.0001653262,0.00003691738,0.000116079,0.0001765473,0.0001141253],"domain_scores_gemma":[0.9992732,0.0002984821,0.00006529026,0.00008202435,0.00009795678,0.0001830069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006713881,0.0002478339,0.0009600234,0.0008683653,0.0000683403,0.001937132,0.0003348694,0.001238272,0.0200051,0.5194849,0.2934387,0.160745],"study_design_scores_gemma":[0.0001523752,0.0002320148,0.0001537235,0.000138982,0.00002628374,0.0009803821,0.0001775512,0.001139565,0.007071032,0.1094729,0.8804157,0.00003936084],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01495953,0.09771915,0.03468332,0.7450312,0.03757829,0.0001373592,0.0004455294,0.0006747321,0.06877088],"genre_scores_gemma":[0.2601922,0.06627507,0.05080343,0.4794957,0.01397643,0.0005303444,0.000328325,0.0003484531,0.1280501],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.005641663,"threshold_uncertainty_score":0.01887327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006746109478845888,"score_gpt":0.2347602020784629,"score_spread":0.228014092599617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}