{"id":"W2514181687","doi":"10.1371/journal.ppat.1005815","title":"Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Basic Energy Sciences; National Institute of General Medical Sciences; Ragon Institute of MGH, MIT and Harvard; Office of Science; National Cancer Institute; International AIDS Vaccine Initiative; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; U.S. Department of Energy","keywords":"Virology; Epitope; Antibody; HIV vaccine; Biology; Human immunodeficiency virus (HIV); Germline; AIDS Vaccines; Neutralization; Antigen; Computational biology; Mutation; Immunology; Genetics; Gene; Vaccine trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006095454,0.0004689481,0.0004038614,0.0003449127,0.0002030288,0.0005794151,0.0006143033,0.0003673177,0.0009592666],"category_scores_gemma":[0.000620519,0.0003419482,0.0003226954,0.000184571,0.0004268495,0.0004053059,0.000392874,0.001322364,0.0002895396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007334823,"about_ca_system_score_gemma":0.0005922401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004000747,"about_ca_topic_score_gemma":0.001123184,"domain_scores_codex":[0.9997471,0.00006376426,0.00001332299,0.00004511058,0.00008862471,0.00004202568],"domain_scores_gemma":[0.9998405,0.00004646028,0.0000399685,0.00002803238,0.00002824081,0.00001685783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001320847,0.0001615819,0.0006830879,0.0001497454,0.000026729,0.0000624286,0.00006434086,0.01571929,0.9521161,0.01118356,0.0002567019,0.01944437],"study_design_scores_gemma":[0.00007667425,0.001329446,0.0009733773,0.00003407423,0.00006377315,0.0002628821,0.00006309801,0.06047862,0.9098254,0.009710566,0.01715368,0.00002830475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6394775,0.002563617,0.3489837,0.0006576648,0.00008831497,0.0007291039,0.0004103537,0.0004532168,0.006636545],"genre_scores_gemma":[0.7585582,0.001533013,0.2366634,0.0002869804,0.000023644,0.0003800751,0.0003817769,0.00007753375,0.00209551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009592666,"threshold_uncertainty_score":0.005321801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03221577681411796,"score_gpt":0.2761790972127249,"score_spread":0.2439633203986069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}