{"id":"W2514206384","doi":"10.1158/2159-8290.cd-16-0789","title":"Activating TCR Signaling to Thwart T-ALL","year":2016,"lang":"en","type":"letter","venue":"Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"T-cell receptor; CD3; T cell; Biology; Apoptosis; Cell biology; Negative selection; Cancer research; Programmed cell death; Leukemia; Immunology; Cancer; CD8; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107318,0.0005824763,0.000629604,0.0003494096,0.0007036183,0.001116312,0.0005452392,0.006968711,0.003154095],"category_scores_gemma":[0.003538883,0.0002388747,0.0006087283,0.0001759719,0.001018838,0.001219808,0.0006851749,0.0110494,0.004433312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001686575,"about_ca_system_score_gemma":0.0007128956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003823286,"about_ca_topic_score_gemma":0.0009428774,"domain_scores_codex":[0.9993218,0.0001527546,0.00006485232,0.00007561224,0.0002701634,0.0001148944],"domain_scores_gemma":[0.999118,0.0004567137,0.00006821714,0.00007146286,0.0001536149,0.0001318502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003498353,0.000265106,0.001247065,0.0003560853,0.00005556332,0.004544486,0.0001367964,0.0004395792,0.009416061,0.01554961,0.7510037,0.2166362],"study_design_scores_gemma":[0.0004459534,0.000558928,0.001253462,0.0003360402,0.00003866215,0.006610634,0.0001306757,0.0009556005,0.004521319,0.02185524,0.9632646,0.00002889859],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.01138216,0.03770651,0.001629415,0.8912528,0.03609018,0.00009678239,0.0001563693,0.000483744,0.02120218],"genre_scores_gemma":[0.1350301,0.0445088,0.002281994,0.6819287,0.0940995,0.000193073,0.0001993591,0.0001120826,0.04164642],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006968711,"threshold_uncertainty_score":0.01223701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05794416019105975,"score_gpt":0.3535519710217933,"score_spread":0.2956078108307335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}