{"id":"W2514206384","doi":"10.1158/2159-8290.cd-16-0789","title":"Activating TCR Signaling to Thwart T-ALL","year":2016,"lang":"en","type":"letter","venue":"Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"T-cell receptor; CD3; T cell; Biology; Apoptosis; Cell biology; Negative selection; Cancer research; Programmed cell death; Leukemia; Immunology; Cancer; CD8; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003605665,0.0004404703,0.0009438252,0.0002997322,0.00006930991,0.0001494852,0.0003364052,0.0005356902,0.00686163],"category_scores_gemma":[0.0001411152,0.0003128282,0.0004198294,0.0002318945,0.0001613655,0.0002371593,0.0001881414,0.001751761,0.0002598786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001077625,"about_ca_system_score_gemma":0.0007795686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003460699,"about_ca_topic_score_gemma":0.00001064228,"domain_scores_codex":[0.9967474,0.000123164,0.000403598,0.0007876017,0.001004841,0.0009334034],"domain_scores_gemma":[0.9981884,0.0005094096,0.0001567276,0.00081307,0.0001495192,0.0001828904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001252804,0.00001131325,0.0001350249,0.0004672709,0.000498747,0.0003343709,0.0002429187,0.000005864276,0.1034871,0.00001452123,0.8706155,0.02293457],"study_design_scores_gemma":[0.002963937,0.0001002728,0.00002227547,0.002105758,0.0001065675,0.00001759327,0.00002483863,0.00000414271,0.02621474,0.0001287718,0.9679132,0.0003979247],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01192007,0.001543951,0.0006518936,0.9558678,0.001526837,0.001684829,0.0002317202,0.0001331415,0.0264398],"genre_scores_gemma":[0.002390872,0.0004441819,0.0001047104,0.7038923,0.02703302,0.0004917867,0.000132693,0.0002170001,0.2652934],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2519755,"threshold_uncertainty_score":0.9999324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05794416019105975,"score_gpt":0.3535519710217933,"score_spread":0.2956078108307335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}