{"id":"W2514442392","doi":"10.1016/j.str.2016.08.003","title":"A New Phase in ALS Research","year":2016,"lang":"nl","type":"letter","venue":"Structure","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Mutation; Mutant; RNA; Crystallography; Chemistry; Biophysics; Molecular biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02237059,0.001171427,0.002878463,0.001536669,0.009435852,0.01266315,0.003941601,0.08763187,0.0148874],"category_scores_gemma":[0.07778083,0.001223415,0.002335055,0.001252704,0.02043742,0.02616661,0.01140305,0.09533878,0.007770446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01146728,"about_ca_system_score_gemma":0.01862856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003802391,"about_ca_topic_score_gemma":0.009488791,"domain_scores_codex":[0.9802187,0.008087367,0.002338009,0.001603095,0.005589721,0.00216313],"domain_scores_gemma":[0.9148231,0.04576618,0.004104531,0.003755264,0.009971847,0.02157921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001170549,0.00007727079,0.0003846516,0.000241982,0.00002936722,0.001190664,0.0002509057,0.00005467971,0.0002072733,0.01848602,0.9601268,0.01883334],"study_design_scores_gemma":[0.0005310095,0.0001333945,0.0005297909,0.000941006,0.00003871221,0.001606387,0.0008931461,0.0004137265,0.0001471151,0.08111499,0.9135675,0.00008323283],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.00009499145,0.002222649,0.00009989121,0.9793674,0.01720815,0.000006206383,0.000010147,0.00001205987,0.0009785551],"genre_scores_gemma":[0.002570797,0.00212192,0.0004389528,0.9028457,0.08876421,0.00004619726,0.00002501494,0.00001770043,0.003169552],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.08763187,"threshold_uncertainty_score":0.1183084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09400474291107257,"score_gpt":0.4467515384878943,"score_spread":0.3527467955768217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}