{"id":"W2514491563","doi":"10.1016/j.freeradbiomed.2015.10.244","title":"A Mitochondria-Targeted Anti-Apoptotic Inhibitor of Cytochrome C Peroxidase Activity Interferes with Mitochondrial Bioenergetics and Does Not Prevent Cell Death in Cultured Cells Reliant on Aerobic Metabolism","year":2015,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brock University","funders":"","keywords":"Bioenergetics; Mitochondrion; Apoptosis; Cytochrome c; Cell biology; Programmed cell death; Cell metabolism; Cytochrome; Chemistry; Metabolism; Peroxidase; Cell; Energy metabolism; Biochemistry; Biology; Enzyme; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004147734,0.0005452979,0.0007848387,0.0004292179,0.0003058118,0.0004658751,0.000723567,0.0005887179,0.001342633],"category_scores_gemma":[0.0003729961,0.0003408233,0.0004261766,0.0003678355,0.0005281956,0.000535623,0.0002338906,0.001337373,0.0003216238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004312751,"about_ca_system_score_gemma":0.0006431393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006821,"about_ca_topic_score_gemma":0.001184493,"domain_scores_codex":[0.9996989,0.00005003107,0.00003293231,0.000052665,0.00007800942,0.00008750099],"domain_scores_gemma":[0.9994934,0.0001939452,0.00008725603,0.00009886074,0.00004419395,0.00008238638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007249956,0.0001680568,0.0001563882,0.00005509459,0.00002285925,0.0001160676,0.00002618042,0.0001033619,0.9965579,0.0003262785,0.0001048371,0.001637974],"study_design_scores_gemma":[0.00004875353,0.0004410252,0.0008110905,0.000003159191,0.00002402019,0.0002068636,0.00001292467,0.0007132326,0.9971078,0.00004651867,0.0005810459,0.000003573525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915241,0.001821792,0.004557401,0.0001671218,0.0001000334,0.00004176842,0.0002502117,0.0001968947,0.001340714],"genre_scores_gemma":[0.9943724,0.0008583718,0.00228235,0.0000496017,0.00002342581,0.00003724296,0.0005155152,0.0000344478,0.001826614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001342633,"threshold_uncertainty_score":0.004491508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302025040992405,"score_gpt":0.2524323990772289,"score_spread":0.2394121486673049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}