{"id":"W2514523591","doi":"10.1007/s10637-016-0383-2","title":"Adding checkpoint inhibitors to tyrosine kinase inhibitors targeting EGFR/ALK in non-small cell lung cancer: a new therapeutic strategy","year":2016,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Nivolumab; Pembrolizumab; Medicine; Lung cancer; Tyrosine kinase; Erlotinib; EGFR inhibitors; Cancer research; Oncology; Anaplastic lymphoma kinase; Internal medicine; Immunotherapy; Cancer; Epidermal growth factor receptor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698273,0.000312859,0.0003232629,0.000284003,0.0001117517,0.00005095402,0.0001155428,0.0001152762,0.0002687918],"category_scores_gemma":[0.00008534069,0.0002340999,0.000114091,0.0005810012,0.00006809304,0.0002286441,0.00005137249,0.0001825155,0.00006553515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009343074,"about_ca_system_score_gemma":0.00252488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004400869,"about_ca_topic_score_gemma":0.0003256305,"domain_scores_codex":[0.997987,0.00003723732,0.0005928629,0.0005136012,0.0004116594,0.0004575993],"domain_scores_gemma":[0.9986173,0.0001325232,0.0001774034,0.0002099745,0.0001309954,0.0007317959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000267389,0.0004473253,0.1793735,0.0003281287,0.0003402914,0.0001105759,0.01196271,0.003112093,0.6177031,0.001762217,0.08862023,0.09597253],"study_design_scores_gemma":[0.03031391,0.001055205,0.1235491,0.009854873,0.001082843,0.00003963865,0.002580576,0.001782983,0.760756,0.007768711,0.05894799,0.002268167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615828,0.002623458,0.000717504,0.03009374,0.0005693976,0.001336724,0.00005593333,0.0001107484,0.002909725],"genre_scores_gemma":[0.9829172,0.00007787909,0.006225011,0.002342181,0.001354029,0.000151586,0.00008336317,0.00006416434,0.006784523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.143053,"threshold_uncertainty_score":0.9546316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607847236170796,"score_gpt":0.2932689510862317,"score_spread":0.2771904787245237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}