{"id":"W2514650201","doi":"10.1016/j.virol.2016.08.007","title":"Role of Herpes simplex virus 1 VP11/12 tyrosine-based binding motifs for Src family kinases, p85, Grb2 and Shc in activation of the phosphoinositide 3-kinase-Akt pathway","year":2016,"lang":"en","type":"article","venue":"Virology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Protein kinase B; GRB2; Biology; PI3K/AKT/mTOR pathway; Proto-oncogene tyrosine-protein kinase Src; Phosphoinositide 3-kinase; Cell biology; Receptor tyrosine kinase; Signal transduction; Kinase; SH3 domain; Tyrosine kinase; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000208417,0.0003303681,0.0001540475,0.0002352291,0.0003328828,0.0004846776,0.0002267141,0.0003150666,0.001493917],"category_scores_gemma":[0.0001585774,0.0001751734,0.0001858109,0.0001332841,0.0002198284,0.0003543537,0.0002837394,0.0004363211,0.0003140494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005485015,"about_ca_system_score_gemma":0.0003859615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007314622,"about_ca_topic_score_gemma":0.001010635,"domain_scores_codex":[0.9998853,0.00002448574,0.000008253159,0.00001500864,0.00002370026,0.00004321865],"domain_scores_gemma":[0.9999269,0.00001648029,0.0000154307,0.000008677788,0.000009007068,0.00002352992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001612392,0.0001145848,0.001180243,0.00009285748,0.00002021631,0.0003779039,0.00005937412,0.0003481673,0.9894788,0.002107555,0.000218255,0.004389675],"study_design_scores_gemma":[0.0001606809,0.0003955304,0.05335557,0.00003471629,0.00006279813,0.001807521,0.0002153267,0.006718693,0.9296058,0.001254981,0.006372024,0.00001635674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930438,0.003382592,0.001021284,0.0001219064,0.00002963528,0.00001287635,0.0001178272,0.00002407363,0.002246135],"genre_scores_gemma":[0.996457,0.0008210376,0.0004187473,0.00001875479,0.000007448949,0.00001067784,0.0001946134,0.000004170726,0.002067368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493917,"threshold_uncertainty_score":0.004997671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126123874690097,"score_gpt":0.2102309803839793,"score_spread":0.1989697416370784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}