{"id":"W2514747241","doi":"10.3324/haematol.2016.146894","title":"Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells","year":2016,"lang":"en","type":"letter","venue":"Haematologica","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"","keywords":"Myeloid leukemia; Myeloid; Cancer research; Pharmacology; Leukemia; Chemistry; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0004739908,0.001049995,0.001908424,0.0004360633,0.0001846334,0.00007756853,0.0007073241,0.001635385,0.001212505],"category_scores_gemma":[0.00006308601,0.0005275659,0.0003874317,0.0006085088,0.0008962943,0.0001462265,0.0001726508,0.003268264,0.0007546179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007310212,"about_ca_system_score_gemma":0.0007167126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009011568,"about_ca_topic_score_gemma":0.00002633917,"domain_scores_codex":[0.9949689,0.0004349787,0.0009234885,0.001272528,0.001087632,0.00131249],"domain_scores_gemma":[0.9964715,0.0008505464,0.0006996557,0.001578626,0.0001979957,0.0002016437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001456386,0.00005652048,0.00009585348,0.0002982526,0.000366263,0.01391759,0.000208844,0.000001967442,0.01340616,0.00004365084,0.9695746,0.0005739049],"study_design_scores_gemma":[0.00498735,0.0007678213,0.00005814265,0.001833949,0.0003382514,0.003237022,0.00004462414,0.0000102692,0.09749421,0.0001804695,0.8902591,0.0007887265],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.05926455,0.0019913,0.0001339424,0.9298998,0.001113575,0.002140727,0.0003664529,0.000448688,0.004641033],"genre_scores_gemma":[0.06870414,0.001609939,0.00104144,0.9010054,0.0100316,0.001461503,0.0004390824,0.0003693104,0.01533762],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.08408805,"threshold_uncertainty_score":0.9997176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747019377326548,"score_gpt":0.2635668604704489,"score_spread":0.2460966666971834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}