{"id":"W2514747241","doi":"10.3324/haematol.2016.146894","title":"Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells","year":2016,"lang":"en","type":"letter","venue":"Haematologica","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"","keywords":"Myeloid leukemia; Myeloid; Cancer research; Pharmacology; Leukemia; Chemistry; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005477512,0.0003725839,0.0008701307,0.0001986572,0.0007096014,0.001147295,0.0004379596,0.005044811,0.002445915],"category_scores_gemma":[0.002585155,0.0001776807,0.0005075751,0.0002438675,0.0003757172,0.0006262205,0.0003315807,0.004663,0.001847417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001243413,"about_ca_system_score_gemma":0.0005190884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006025677,"about_ca_topic_score_gemma":0.001796702,"domain_scores_codex":[0.9995118,0.0001403555,0.00006503995,0.00003368114,0.0001561387,0.00009296317],"domain_scores_gemma":[0.9994453,0.0002743487,0.00006324375,0.00003723352,0.00006393984,0.0001158639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003314656,0.0008068684,0.008632572,0.0005345741,0.0001553333,0.04985792,0.000216157,0.00244564,0.02178332,0.007930393,0.657104,0.2472186],"study_design_scores_gemma":[0.003227142,0.002726304,0.01442933,0.0003005512,0.0002073888,0.05830261,0.000363468,0.0103015,0.02181542,0.01492292,0.8733131,0.00009037741],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.09697406,0.02169191,0.001657638,0.8122653,0.02259569,0.0001700112,0.0007045686,0.0004655485,0.04347537],"genre_scores_gemma":[0.5948498,0.02326205,0.002927262,0.2985187,0.03087895,0.0002493667,0.0008164225,0.00007237964,0.04842501],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005044811,"threshold_uncertainty_score":0.00902164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747019377326548,"score_gpt":0.2635668604704489,"score_spread":0.2460966666971834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}