{"id":"W2514978986","doi":"10.1182/blood.v126.23.571.571","title":"Disruptive ARID1A Mutations in Follicular Lymphoma Impair DNA Repair Efficiency and Are Associated with Favorable Outcome in Patients Receiving First-Line Immunochemotherapy","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"ARID1A; Follicular lymphoma; Lymphoma; Cancer research; Internal medicine; Oncology; Medicine; Aggressive lymphoma; Mutation; Biology; Immunology; Rituximab; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003235087,0.0001730478,0.0002823219,0.0004620159,0.0002667458,0.0003867196,0.0001942348,0.000276517,0.001650742],"category_scores_gemma":[0.001619592,0.0001071132,0.0002423906,0.000374744,0.0002173698,0.0002264272,0.000190997,0.000336192,0.0002364086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002466055,"about_ca_system_score_gemma":0.0001431104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006016243,"about_ca_topic_score_gemma":0.0005761824,"domain_scores_codex":[0.9997906,0.00004265036,0.00002507795,0.00004670094,0.00004622523,0.00004881203],"domain_scores_gemma":[0.9989716,0.0002424845,0.0004591269,0.00006141287,0.00008615827,0.0001793259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005067707,0.00003658425,0.9921102,0.00001107949,0.00003899241,0.0006587105,0.00004381857,0.00007856346,0.003254221,0.00001980103,0.0001199464,0.003121441],"study_design_scores_gemma":[0.0000155491,0.0001982215,0.9941718,0.000006760804,0.00004982987,0.004018068,0.0001084308,0.0003663677,0.0006903348,0.00006982281,0.0003000026,0.000004766206],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993687,0.0002655213,0.00005406522,0.00002046823,0.000003409107,0.000002610655,0.00005086267,0.000003669747,0.0002306286],"genre_scores_gemma":[0.9998423,0.00003489337,0.00002204003,0.000007187221,0.000004319398,0.000001076278,0.00005486301,6.51426e-7,0.00003261692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001650742,"threshold_uncertainty_score":0.005522311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128356392371144,"score_gpt":0.2418024145507276,"score_spread":0.2305188506270162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}