{"id":"W2515133122","doi":"10.1038/nchembio.2158","title":"HDAC6 finally crystal clear","year":2016,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"","keywords":"HDAC6; Computational biology; Chemistry; Crystallography; Biology; Biochemistry; Histone; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001328623,0.0008232414,0.0007078174,0.0002468494,0.001620574,0.002865029,0.0009102069,0.007623237,0.01472009],"category_scores_gemma":[0.006759432,0.0004404263,0.0007372901,0.0001482529,0.002059458,0.002298791,0.001916444,0.01660962,0.009293051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002616923,"about_ca_system_score_gemma":0.001338617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002488635,"about_ca_topic_score_gemma":0.003841093,"domain_scores_codex":[0.999029,0.0001019133,0.00005627695,0.0001363371,0.0004563106,0.000220018],"domain_scores_gemma":[0.998996,0.0002140308,0.00008457935,0.0001196354,0.0002127014,0.000373189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002408328,0.00003346517,0.0003011429,0.0001360124,0.00005111392,0.001229863,0.00009222248,0.0001723003,0.006370659,0.05675139,0.908109,0.02651195],"study_design_scores_gemma":[0.000102683,0.00005253009,0.0001867203,0.00003451838,0.00001797418,0.0005337418,0.00007876786,0.0002679646,0.006466993,0.02514151,0.9670936,0.0000229143],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.004922514,0.01690691,0.003088855,0.8332184,0.09615455,0.00003332579,0.0004283015,0.0007417277,0.04450542],"genre_scores_gemma":[0.1160686,0.01504416,0.003211204,0.5269538,0.03337643,0.0001110755,0.0008643738,0.0005864457,0.303784],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01472009,"threshold_uncertainty_score":0.04924357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006613389870461875,"score_gpt":0.2793730046179343,"score_spread":0.2727596147474724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}