{"id":"W2515138490","doi":"10.1002/ijc.30288","title":"Telomere structure and maintenance gene variants and risk of five cancer types","year":2016,"lang":"en","type":"review","venue":"International Journal of Cancer","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Institute of Cancer Research","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Cancer Research UK; National Institute on Aging; Francis Crick Institute; National Human Genome Research Institute; World Health Organization","keywords":"Telomere; Biology; Single-nucleotide polymorphism; Prostate cancer; Prostate; Colorectal cancer; Breast cancer; Oncology; Telomerase reverse transcriptase; Cancer; Lung cancer; Internal medicine; Cancer research; Telomerase; Gene; Genetics; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001281684,0.0007159516,0.001116119,0.001043407,0.0005456582,0.001029694,0.0005461965,0.0008872016,0.002544125],"category_scores_gemma":[0.002438955,0.0004485635,0.005631504,0.002216476,0.0002949313,0.0002490729,0.0006940385,0.0009124733,0.0001762057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003565316,"about_ca_system_score_gemma":0.0003379502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007103081,"about_ca_topic_score_gemma":0.00991895,"domain_scores_codex":[0.9989298,0.0002009716,0.0001188702,0.0005224377,0.0001093712,0.0001186428],"domain_scores_gemma":[0.9981026,0.0007969767,0.0005364746,0.0002543256,0.0001384552,0.0001711345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00763041,0.00006371604,0.9104466,0.001345517,0.05932436,0.0004198749,0.0001266248,0.001612632,0.004744139,0.0002861487,0.0009346692,0.01306529],"study_design_scores_gemma":[0.0005199147,0.0004942365,0.9352832,0.0002467131,0.05581643,0.000830645,0.0001078823,0.002254604,0.00155319,0.0005345174,0.002315209,0.00004339998],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9621409,0.03108364,0.001270344,0.0002237366,0.00007932345,0.00003011488,0.004083872,0.00006516231,0.001022883],"genre_scores_gemma":[0.9943672,0.002665852,0.0004930379,0.00007377714,0.00003800761,0.00003046911,0.001691079,0.00001687372,0.0006237309],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007103081,"threshold_uncertainty_score":0.0141235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708467282976293,"score_gpt":0.3478297060736974,"score_spread":0.3307450332439344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}