{"id":"W2515269070","doi":"10.1021/jacs.6b07268","title":"Syntheses of Denudatine Diterpenoid Alkaloids: Cochlearenine, <i>N</i>-Ethyl-1α-hydroxy-17-veratroyldictyzine, and Paniculamine","year":2016,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Plant-based Medicinal Research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Terpenoid; Aconitine; Stereochemistry; Diterpene; Organic chemistry; Chromatography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001866907,0.0004230183,0.0003154995,0.0003673881,0.0002435192,0.0001615318,0.0003583728,0.000234931,0.002480618],"category_scores_gemma":[0.0001720271,0.000127031,0.0001875714,0.0003684853,0.0001497824,0.0002716209,0.0003747801,0.0004452511,0.001140557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003011832,"about_ca_system_score_gemma":0.0005673357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005378064,"about_ca_topic_score_gemma":0.001095271,"domain_scores_codex":[0.9999312,0.000007614517,0.000009906721,0.00001462706,0.00001968485,0.00001701913],"domain_scores_gemma":[0.9999336,0.000005110929,0.00001210731,0.00001088389,0.0000145649,0.00002367831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234891,0.0001199764,0.0001779953,0.0005349905,0.0000341036,0.0004856285,0.0002501841,0.0009664085,0.9693667,0.001891456,0.0005314117,0.02551762],"study_design_scores_gemma":[0.0001692317,0.00118536,0.002235573,0.00004415044,0.00006922615,0.0008348695,0.0001193278,0.001078552,0.9431499,0.0007932587,0.05027361,0.00004690114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8771386,0.01275621,0.06600975,0.0004881217,0.0003472811,0.001587151,0.004788395,0.0006388116,0.0362456],"genre_scores_gemma":[0.9293073,0.01033466,0.04772792,0.0001452382,0.00004304018,0.0005061607,0.002154762,0.00006652882,0.009714297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002480618,"threshold_uncertainty_score":0.008298516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05185599028850497,"score_gpt":0.3863815929297713,"score_spread":0.3345256026412664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}