{"id":"W2515277963","doi":"10.1016/j.foodchem.2016.09.026","title":"CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol","year":2016,"lang":"en","type":"article","venue":"Food Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Rat für Forschung und Technologieentwicklung; Department of Psychiatry, University of Toronto; Centre for Addiction and Mental Health Foundation; Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya; National Institutes of Health; Generalitat de Catalunya; Centre for Addiction and Mental Health","keywords":"Tyrosol; Hydroxytyrosol; CYP2A6; Chemistry; Biochemistry; Pharmacology; Biotransformation; Cytochrome P450; CYP3A4; Enzyme; Antioxidant; Polyphenol; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002697438,0.0003351763,0.0003077236,0.000034801,0.0002255296,0.00002093064,0.0003188187,0.0004290644,0.001479594],"category_scores_gemma":[0.00004489652,0.0002556324,0.0001211681,0.0001161605,0.0003601326,0.0001081307,0.0001416318,0.0004423696,0.000125403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004168867,"about_ca_system_score_gemma":0.00007278239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005616258,"about_ca_topic_score_gemma":0.000003367449,"domain_scores_codex":[0.9983466,0.00006383791,0.0003641907,0.0004896048,0.0001737651,0.0005620287],"domain_scores_gemma":[0.9988996,0.0001739516,0.00009580465,0.0002766081,0.00006185098,0.0004921762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001333948,0.0001306328,0.0007902121,0.0001059891,0.0001859957,0.00001753856,0.0002840511,0.000003324223,0.9435223,0.00006718487,0.001486695,0.05327262],"study_design_scores_gemma":[0.001872686,0.00006669365,0.0001548675,0.00001987741,0.0001281367,0.00003679206,0.00003114048,0.00008474215,0.826669,0.001306497,0.1692886,0.0003409507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761239,0.005691723,0.00008652181,0.002170009,0.0006131802,0.0002127416,0.0002377573,0.0001360864,0.01472809],"genre_scores_gemma":[0.9936065,0.002756526,0.0001814864,0.001114881,0.0006321142,0.00005438888,0.00002026673,0.00004207372,0.001591748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1678019,"threshold_uncertainty_score":0.9999896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06607398754303452,"score_gpt":0.3770852513657949,"score_spread":0.3110112638227604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}