{"id":"W2515296740","doi":"10.1097/mib.0000000000000909","title":"Interpreting Registrational Clinical Trials of Biological Therapies in Adults with Inflammatory Bowel Diseases","year":2016,"lang":"en","type":"review","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials; University of Calgary","funders":"","keywords":"Medicine; Clinical trial; Inflammatory bowel disease; Ulcerative colitis; Clinical study design; Intensive care medicine; Disease; Randomized controlled trial; Inflammatory Bowel Diseases; Crohn's disease; Population; Research design; Physical therapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08659287,0.001610514,0.006687144,0.006465202,0.0005558984,0.004680851,0.004340966,0.004127842,0.002609326],"category_scores_gemma":[0.2038271,0.0009334801,0.003430693,0.005856301,0.002552925,0.003799858,0.002004999,0.003049757,0.000858964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00231032,"about_ca_system_score_gemma":0.009099149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001355356,"about_ca_topic_score_gemma":0.002378591,"domain_scores_codex":[0.9142718,0.05380404,0.01922778,0.002578076,0.009655118,0.0004633034],"domain_scores_gemma":[0.7347975,0.2205483,0.02581436,0.004880854,0.01319471,0.0007643143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0005198314,0.00005056928,0.001082626,0.3114091,0.002911792,0.0001587614,0.0003808464,0.0006024071,0.000337305,0.006569972,0.01376669,0.6622102],"study_design_scores_gemma":[0.0007312633,0.0004979203,0.004552589,0.5244535,0.01227415,0.001400814,0.0005450203,0.0004931436,0.001159566,0.02281463,0.4309313,0.0001460915],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001068727,0.9967731,0.0006693217,0.001134356,0.0004612962,0.000165556,0.00005504729,0.00000925816,0.0006252603],"genre_scores_gemma":[0.004299758,0.9887095,0.003596243,0.001931386,0.0007248161,0.0004071757,0.0001139337,0.00001161669,0.0002055497],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.08659287,"threshold_uncertainty_score":0.4579523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0444750518005597,"score_gpt":0.3546535743857396,"score_spread":0.3101785225851799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}