{"id":"W2515297195","doi":"10.1021/acs.molpharmaceut.6b00413","title":"<i>In Vivo</i> Precipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of British Columbia","funders":"Canadian Institutes of Health Research; European Commission; European Federation of Pharmaceutical Industries and Associations","keywords":"In vivo; Stomach; Fenofibrate; Lipolysis; Small intestine; Pharmacology; Danazol; Drug; Chemistry; Precipitation; Medicine; Internal medicine; Biology; Adipose tissue","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001500306,0.0004530793,0.000649615,0.0003103033,0.0001294905,0.00003934537,0.0006026142,0.0004370286,0.0007917064],"category_scores_gemma":[0.00008456413,0.0004047258,0.0002590648,0.0004503967,0.0002974314,0.0003717241,0.0001239999,0.0005470209,0.0002820812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002583667,"about_ca_system_score_gemma":0.0002749411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000794902,"about_ca_topic_score_gemma":0.00006165361,"domain_scores_codex":[0.9953564,0.001503047,0.001085491,0.0006527916,0.0005642753,0.0008379875],"domain_scores_gemma":[0.9972027,0.001111113,0.0004689248,0.0005134803,0.0003103749,0.0003934284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001174871,0.0008561047,0.007383141,0.0003103701,0.0003583753,0.0001677341,0.00159145,0.008055745,0.9572272,0.0007941849,0.01816469,0.003916078],"study_design_scores_gemma":[0.005860556,0.00007436941,0.00008924005,0.0002002299,0.0002575973,0.000005404075,0.0002274178,0.02253381,0.7367933,0.0002601507,0.2331642,0.0005337149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806557,0.003186941,0.002747042,0.001651566,0.006036968,0.001135114,0.0006092695,0.0001562781,0.003821064],"genre_scores_gemma":[0.9944082,0.0003209616,0.0002421091,0.002962709,0.0003114153,0.0001126631,0.00003445019,0.00007092842,0.001536557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2204339,"threshold_uncertainty_score":0.9998404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04975321338565138,"score_gpt":0.361638475474266,"score_spread":0.3118852620886147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}