{"id":"W2515412931","doi":"10.1038/ncomms12628","title":"Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Vontobel-Stiftung; Promedica Stiftung; Universität Zürich; Université de Strasbourg; National Science Foundation; Ministerio de Economía y Competitividad; Eidgenössische Technische Hochschule Zürich; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Ubiquitin ligase; Homologous recombination; DDB1; Ubiquitin; Cell biology; Non-homologous end joining; Proteasome; Biology; DNA ligase; DNA; Molecular biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003456582,0.0001752149,0.0001335584,0.00008563959,0.0001869651,0.00002899428,0.0009603171,0.0004604955,0.00006352465],"category_scores_gemma":[0.0009162584,0.0001366229,0.00009825717,0.0002219448,0.00009032067,0.00001113355,0.0006452339,0.0003519074,0.000104257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005153807,"about_ca_system_score_gemma":0.00008827806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001860592,"about_ca_topic_score_gemma":0.001869436,"domain_scores_codex":[0.9987917,0.0001687786,0.0002391298,0.0003514941,0.0001947782,0.0002541229],"domain_scores_gemma":[0.9971922,0.00006746747,0.0001012578,0.002241364,0.0002550287,0.0001426795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005803837,0.00009231312,0.0001416371,0.000006238778,0.00003293481,8.12733e-7,0.00003474317,0.000001133703,0.9840243,0.002882943,0.01041874,0.002306103],"study_design_scores_gemma":[0.0003256882,0.0001712818,0.0005438117,0.0000509059,0.00001276269,0.000007206233,0.00002004535,0.000007431867,0.771311,0.0004474464,0.2269321,0.0001703413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671292,0.003404706,0.0009924673,0.0236888,0.0003544429,0.0009620514,0.0001606444,0.0001224356,0.003185206],"genre_scores_gemma":[0.9885824,0.0001927092,0.00684563,0.0005421092,0.0002542862,0.0002835646,0.000205888,0.00003815303,0.003055273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2165133,"threshold_uncertainty_score":0.557132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322458375230486,"score_gpt":0.2834113234723671,"score_spread":0.2701867397200622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}