{"id":"W2515412931","doi":"10.1038/ncomms12628","title":"Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Vontobel-Stiftung; Promedica Stiftung; Universität Zürich; Université de Strasbourg; National Science Foundation; Ministerio de Economía y Competitividad; Eidgenössische Technische Hochschule Zürich; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Ubiquitin ligase; Homologous recombination; DDB1; Ubiquitin; Cell biology; Non-homologous end joining; Proteasome; Biology; DNA ligase; DNA; Molecular biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001952933,0.0002994087,0.0001851092,0.0001374145,0.0001712571,0.0003935101,0.0002820386,0.0002397193,0.0009344688],"category_scores_gemma":[0.0001120583,0.0001119467,0.0002316544,0.0001282837,0.0002317123,0.0002678153,0.0004398817,0.0003316291,0.00050731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005348254,"about_ca_system_score_gemma":0.0002310095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005208501,"about_ca_topic_score_gemma":0.0007672723,"domain_scores_codex":[0.9998367,0.00001628957,0.00001848432,0.00004701018,0.00003573611,0.00004579637],"domain_scores_gemma":[0.9998789,0.00001282511,0.0000443183,0.00001951422,0.000009085346,0.00003540669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008242021,0.000008486132,0.0005530783,0.00002522067,0.000005341765,0.00004605721,0.000006703206,0.00009898937,0.9979928,0.0001078133,0.0000291942,0.001043876],"study_design_scores_gemma":[0.000008974977,0.00003707887,0.00389214,0.000002641391,0.000005137516,0.0002009978,0.0000123947,0.0009394365,0.9939274,0.00003259678,0.0009383366,0.000002885796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927235,0.001216804,0.004741798,0.000066332,0.00001357298,0.00001513372,0.0002158454,0.00007950554,0.0009274234],"genre_scores_gemma":[0.997537,0.0001865301,0.001140174,0.00002137065,0.000001805939,0.000007050948,0.000177744,0.000009601019,0.0009187773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009344688,"threshold_uncertainty_score":0.003880501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322458375230486,"score_gpt":0.2834113234723671,"score_spread":0.2701867397200622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}