{"id":"W2515414172","doi":"10.1007/s40262-016-0442-z","title":"Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence","year":2016,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"U.S. Food and Drug Administration","keywords":"Bioequivalence; Pharmacokinetics; Medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002707095,0.0007529261,0.000920901,0.0001984551,0.0004079526,0.0001038635,0.003356701,0.000584482,0.009685177],"category_scores_gemma":[0.0008000975,0.0005621385,0.0003709039,0.0005750509,0.0009200365,0.0004340203,0.002256843,0.001501717,0.004908957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000177938,"about_ca_system_score_gemma":0.0002618549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000134615,"about_ca_topic_score_gemma":0.000001713731,"domain_scores_codex":[0.9923316,0.001925746,0.001857872,0.001711182,0.0006987896,0.001474789],"domain_scores_gemma":[0.9951775,0.001601005,0.000315046,0.0008452741,0.0004192769,0.001641897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003995488,0.003504381,0.005052438,0.0001125122,0.000479086,0.0001876591,0.0002646781,0.002726512,0.2289437,0.0004580904,0.0706243,0.6836511],"study_design_scores_gemma":[0.01569582,0.0009412064,0.001858943,0.0001180633,0.0008370486,0.0001081427,0.00003617546,0.01512684,0.08406031,0.0006574951,0.8792744,0.001285547],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8088328,0.001448343,0.0650649,0.01801167,0.01298632,0.006864345,0.0005703497,0.0006616685,0.08555964],"genre_scores_gemma":[0.9200922,0.004738332,0.0188736,0.04182834,0.002151931,0.000404467,0.00004483141,0.0001683408,0.01169796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8086501,"threshold_uncertainty_score":0.999683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.283421452958704,"score_gpt":0.5430172333162642,"score_spread":0.2595957803575601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}