{"id":"W2515546929","doi":"10.1016/j.ccell.2016.07.006","title":"EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis","year":2016,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Roche; American Society of Hematology; Leukemia and Lymphoma Society; National Institute of General Medical Sciences; American Heart Association","keywords":"PRC2; Germinal center; Chromatin; BCL6; EZH2; Biology; Chromodomain; Promoter; Histone methyltransferase; Cancer research; Bivalent chromatin; Histone; Cell biology; Histone H2A; B cell; Genetics; DNA; Gene; Antibody; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203154,0.0005036624,0.0002589577,0.0004428305,0.000490429,0.0007400965,0.0004878471,0.0002727612,0.002813264],"category_scores_gemma":[0.0001794824,0.000317133,0.0002385538,0.0002365468,0.0002617585,0.0005533068,0.0009892937,0.0007085689,0.001319089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007401558,"about_ca_system_score_gemma":0.0002794842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008285638,"about_ca_topic_score_gemma":0.002045942,"domain_scores_codex":[0.999742,0.00002890172,0.00001673476,0.00005392554,0.00008246828,0.00007606868],"domain_scores_gemma":[0.9998465,0.00001086833,0.00003412099,0.00002173774,0.00002019929,0.0000666566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001302684,0.00001600562,0.0009446004,0.00002719938,0.000009489194,0.00008220036,0.00001740886,0.00003968625,0.9963431,0.0005415929,0.0001141955,0.001734258],"study_design_scores_gemma":[0.00002430173,0.00003288187,0.008360373,0.000001755771,0.00001093804,0.0002354157,0.00003355818,0.0007421707,0.9871185,0.0001303215,0.003306424,0.000003401969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767333,0.003490797,0.0125827,0.0002107847,0.00006419393,0.00004050661,0.0004757061,0.0004910458,0.005910947],"genre_scores_gemma":[0.9889069,0.0002727164,0.002435053,0.00004291886,0.0000121815,0.00001894531,0.0005884041,0.00004803907,0.007674932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002813264,"threshold_uncertainty_score":0.009411275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01960090312651046,"score_gpt":0.2787189903698256,"score_spread":0.2591180872433151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}