{"id":"W2515546929","doi":"10.1016/j.ccell.2016.07.006","title":"EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis","year":2016,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Roche; American Society of Hematology; Leukemia and Lymphoma Society; National Institute of General Medical Sciences; American Heart Association","keywords":"PRC2; Germinal center; Chromatin; BCL6; EZH2; Biology; Chromodomain; Promoter; Histone methyltransferase; Cancer research; Bivalent chromatin; Histone; Cell biology; Histone H2A; B cell; Genetics; DNA; Gene; Antibody; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098992,0.0001199106,0.0001075357,0.00002741421,0.00005929487,0.00003408279,0.00006981658,0.00006281442,0.00003050019],"category_scores_gemma":[0.00001495539,0.00009198416,0.00002026667,0.00004111005,0.00002193265,0.000009905012,0.0001131352,0.0000138286,0.00000793136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003191845,"about_ca_system_score_gemma":0.00002792756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005451014,"about_ca_topic_score_gemma":0.0001388597,"domain_scores_codex":[0.9992219,0.00003706467,0.0001568747,0.0003160271,0.00008232857,0.0001858113],"domain_scores_gemma":[0.9994962,0.000007701142,0.00005073646,0.0001925,0.0000868854,0.0001659641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006253242,0.00001821744,0.004025706,0.00003517501,0.000007657351,9.329102e-7,0.0001145258,0.00001495324,0.9596677,0.000001737185,0.000678417,0.03537243],"study_design_scores_gemma":[0.0006820324,0.0002205091,0.02299319,0.00003240457,0.00001423216,0.000002110194,0.00002138422,0.00008451402,0.9243462,0.000008279452,0.05141892,0.0001762384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991823,0.001643851,0.005151681,0.00050551,0.0001212477,0.0002939815,0.00007603119,0.000007247459,0.0003774786],"genre_scores_gemma":[0.9950817,0.002600887,0.0009623592,0.0003408537,0.0001396838,0.0000614658,0.00003115112,0.00001759621,0.000764296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0507405,"threshold_uncertainty_score":0.3751005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01960090312651046,"score_gpt":0.2787189903698256,"score_spread":0.2591180872433151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}