{"id":"W2515620899","doi":"10.1084/jem.20150376","title":"IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization","year":2016,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Consejo Nacional de Ciencia y Tecnología; Deutsche Forschungsgemeinschaft","keywords":"Keratinocyte; Immunology; Interleukin 22; Inflammation; Endogeny; Human skin; Atopic dermatitis; Cytokine; Interleukin 23; Epidermis (zoology); Medicine; Cell biology; Biology; Chemistry; Interleukin; Cell culture; Endocrinology; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000517996,0.0002103517,0.0005223365,0.0003578751,0.0001099512,0.000009265597,0.0002696322,0.00007520439,0.0002605132],"category_scores_gemma":[0.0007113155,0.0001110016,0.00006486302,0.0003001901,0.0001590981,0.0001274,0.00007743773,0.0002037034,0.00005196477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001607119,"about_ca_system_score_gemma":0.0001175598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005316405,"about_ca_topic_score_gemma":0.000004313753,"domain_scores_codex":[0.998198,0.0002546975,0.0006686713,0.0001464587,0.0004323062,0.0002998424],"domain_scores_gemma":[0.9984194,0.0006241583,0.0001922514,0.0002792576,0.0001442429,0.0003407065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003208385,0.0003200232,0.002932878,0.000008946062,0.00007098285,0.0002877104,0.004899805,6.874746e-7,0.976984,0.00001535743,0.01074173,0.000529551],"study_design_scores_gemma":[0.003986055,0.002610324,0.005922159,0.0008290568,0.00009952683,0.001758007,0.005066793,0.000001882443,0.9789984,0.00003328606,0.0005673921,0.0001271726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985788,0.004727708,0.00009272305,0.008220286,0.0004046881,0.0004117393,0.00001574082,0.00001434125,0.0003247726],"genre_scores_gemma":[0.996053,0.0002191398,0.0001391626,0.002897791,0.0002512461,0.0000115296,0.000004962268,0.00002641568,0.0003967123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01026504,"threshold_uncertainty_score":0.4526513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02232236321099489,"score_gpt":0.2995082948447783,"score_spread":0.2771859316337834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}