{"id":"W2515620899","doi":"10.1084/jem.20150376","title":"IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization","year":2016,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Consejo Nacional de Ciencia y Tecnología; Deutsche Forschungsgemeinschaft","keywords":"Keratinocyte; Immunology; Interleukin 22; Inflammation; Endogeny; Human skin; Atopic dermatitis; Cytokine; Interleukin 23; Epidermis (zoology); Medicine; Cell biology; Biology; Chemistry; Interleukin; Cell culture; Endocrinology; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001453978,0.0003212935,0.0002569993,0.0001943367,0.0001519655,0.0004615898,0.0001033148,0.0002775614,0.001737985],"category_scores_gemma":[0.0001010662,0.0001216589,0.0003041241,0.00009421055,0.000190474,0.0001457299,0.0002314014,0.001002474,0.0009366919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002342323,"about_ca_system_score_gemma":0.0002323713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002348535,"about_ca_topic_score_gemma":0.0003997424,"domain_scores_codex":[0.9997876,0.00004003524,0.00001772414,0.00002637521,0.00004644945,0.00008178093],"domain_scores_gemma":[0.9999187,0.00001093426,0.00001426504,0.00001454334,0.00001026889,0.00003131135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006564681,0.0000403414,0.0001012584,0.00001914174,0.000002407298,0.00005160905,0.000008750688,0.00004377606,0.9987871,0.0000439684,0.00003687046,0.0007991167],"study_design_scores_gemma":[0.00002280015,0.0003743466,0.002192288,0.000009728285,0.00001516525,0.0002723032,0.00003632358,0.0005044196,0.9944025,0.00006714533,0.002099496,0.000003628222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911858,0.001576975,0.002368029,0.0002183831,0.0001157994,0.00009158729,0.0003550879,0.0001027817,0.003985586],"genre_scores_gemma":[0.9948928,0.0008401836,0.001544568,0.0001479083,0.00002952548,0.00005315159,0.0002007103,0.00002002467,0.002271062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737985,"threshold_uncertainty_score":0.005814135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02232236321099489,"score_gpt":0.2995082948447783,"score_spread":0.2771859316337834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}