{"id":"W2515733173","doi":"10.1242/dmm.023374","title":"Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets","year":2016,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Biology; Intracellular; Mitochondrion; Cancer cell; Glycolysis; Biochemistry; Cell biology; Respiratory chain; Metabolism; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001851774,0.0004172114,0.0003623579,0.0005028234,0.000127427,0.0003204058,0.0002325236,0.0002172182,0.0008083154],"category_scores_gemma":[0.000249355,0.0001765013,0.0003889125,0.0006655143,0.0002139277,0.0001235882,0.0002427269,0.0003905009,0.0003994506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667634,"about_ca_system_score_gemma":0.0002407287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049348,"about_ca_topic_score_gemma":0.001059779,"domain_scores_codex":[0.9998614,0.00001810669,0.00002127881,0.00003642885,0.00004232322,0.00002045456],"domain_scores_gemma":[0.9996548,0.000117762,0.00009457817,0.00004567421,0.00004408027,0.00004304614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001282091,0.00001289431,0.0005854265,0.00004111935,0.000006851061,0.0000589989,0.00001455924,0.0001770935,0.9972302,0.00005549965,0.00002483353,0.001664256],"study_design_scores_gemma":[0.0000289605,0.0003092206,0.02747423,0.00001450723,0.00007458602,0.0007010017,0.0001163599,0.002742582,0.9639308,0.0001462041,0.004444271,0.00001729035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763998,0.001864378,0.01392577,0.0001568191,0.00003248716,0.0001148901,0.006243239,0.0003319111,0.0009307754],"genre_scores_gemma":[0.9653124,0.001532325,0.01857002,0.0001183043,0.00001214546,0.0001436175,0.01134617,0.0001786042,0.00278639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049348,"threshold_uncertainty_score":0.002704144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008377381778446543,"score_gpt":0.2278791820937305,"score_spread":0.2195018003152839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}