{"id":"W2515871073","doi":"10.1038/srep32118","title":"A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; Heart and Stroke Foundation of Canada","keywords":"Cofilin; Phosphorylation; Rho-associated protein kinase; Vascular smooth muscle; Myosin light-chain kinase; Biochemistry; Biology; Myosin; Kinase; In silico; In vitro; Cytoskeleton; Cell biology; Actin cytoskeleton; Smooth muscle; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006562816,0.0003031037,0.0002569408,0.0001243682,0.0000879353,0.0001910141,0.0002188011,0.0001528701,0.00147214],"category_scores_gemma":[0.00005151227,0.00009913382,0.0001936185,0.00007884675,0.00007773897,0.00008462564,0.0001038967,0.00025709,0.0002405605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001979459,"about_ca_system_score_gemma":0.0001886879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007450393,"about_ca_topic_score_gemma":0.001833158,"domain_scores_codex":[0.9999664,0.000004845711,0.000002712035,0.000008205389,0.000006166041,0.00001157741],"domain_scores_gemma":[0.9999845,0.000002211509,0.00000454212,0.000001446133,0.000002481397,0.000004804728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007015799,0.0001604632,0.0003312759,0.0002731776,0.0000231747,0.0002074321,0.00002029252,0.0009131963,0.9871362,0.0002575635,0.0003585039,0.009617022],"study_design_scores_gemma":[0.0005205704,0.003060033,0.007581029,0.0000208867,0.00009867936,0.0004317863,0.00003165354,0.005913178,0.9741102,0.00008441346,0.008127461,0.00002005403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842973,0.00818395,0.002768303,0.0002276548,0.00007883205,0.00008037614,0.0007066564,0.0001809243,0.00347606],"genre_scores_gemma":[0.9939296,0.002208635,0.001345607,0.00008010337,0.000009358172,0.00004741385,0.0005153943,0.000004695095,0.001859215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00147214,"threshold_uncertainty_score":0.004924834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01041908446563702,"score_gpt":0.2292076454311098,"score_spread":0.2187885609654728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}