{"id":"W2515891401","doi":"10.1186/s13059-016-1043-8","title":"Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders","year":2016,"lang":"en","type":"article","venue":"Genome biology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; The Wilson Centre; Ontario Institute for Cancer Research; University of Toronto; SickKids Foundation","funders":"Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología; Eesti Teadusagentuur; Canada Research Chairs; Canadian Institutes of Health Research; Sick Kids Foundation; Hospital for Sick Children; Wellcome Trust; Wellcome","keywords":"Cohesin; CTCF; Biology; Genetics; Chromatin; Chromosome segregation; Cell biology; Transcription factor; Gene; Chromosome; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009151285,0.000301297,0.0001329904,0.0003193899,0.0002310945,0.0005417221,0.0001981394,0.0002077521,0.002155595],"category_scores_gemma":[0.0002948469,0.0001942728,0.0001610653,0.0001980361,0.0001736984,0.000190803,0.0003340205,0.0001799674,0.0005570807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004203846,"about_ca_system_score_gemma":0.0001654657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001442012,"about_ca_topic_score_gemma":0.001884683,"domain_scores_codex":[0.9998863,0.000008726149,0.000003169414,0.0000341825,0.00003364039,0.00003396083],"domain_scores_gemma":[0.9998438,0.0000190135,0.00004245786,0.00000738623,0.00001736138,0.00006991726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002621622,0.00001529985,0.01280321,0.00008947445,0.00002857,0.0001173079,0.00003078402,0.0002123751,0.9831498,0.0002425353,0.0002001063,0.002848341],"study_design_scores_gemma":[0.0001330043,0.0003883185,0.3229117,0.00007790581,0.0001174791,0.00177476,0.0003438139,0.009939265,0.6534808,0.0006701247,0.01013248,0.00003028855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996348,0.0009718247,0.001323534,0.00002931915,0.000008249711,0.000005816255,0.0001467612,0.00004783926,0.0011187],"genre_scores_gemma":[0.9980799,0.0001767717,0.000644315,0.00001696505,0.00000516982,0.000005369532,0.0003948841,0.000006813063,0.0006698531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002155595,"threshold_uncertainty_score":0.007211208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008373328324225882,"score_gpt":0.2484165369753493,"score_spread":0.2400432086511234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}