{"id":"W2515963470","doi":"10.1021/jacs.6b07588","title":"Homodimericin A: A Complex Hexacyclic Fungal Metabolite","year":2016,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health","funders":"National Center for Complementary and Integrative Health; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Chemistry; Stereocenter; Metabolite; Stereochemistry; Bafilomycin; Molecule; Actinobacteria; Secondary metabolite; Organic chemistry; Biochemistry; Enantioselective synthesis; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007381005,0.0002636967,0.00009891041,0.0002474364,0.0002281973,0.0003448734,0.0001266199,0.0003077516,0.001144263],"category_scores_gemma":[0.00006857245,0.00007980029,0.0001155953,0.0002012153,0.0002086846,0.0004662586,0.0002039764,0.0003083172,0.0003107933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001878809,"about_ca_system_score_gemma":0.0001746164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001277116,"about_ca_topic_score_gemma":0.0001338155,"domain_scores_codex":[0.9999295,0.00001192158,0.000003695586,0.00003142285,0.00001299851,0.00001042319],"domain_scores_gemma":[0.9999335,0.000009035535,0.0000178434,0.00001019277,0.000005313531,0.00002407762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074259,0.00002665318,0.0005572167,0.00003602411,0.000006083552,0.0001528582,0.00002002542,0.0001305784,0.9937258,0.0005869155,0.0000638507,0.004586616],"study_design_scores_gemma":[0.00001180937,0.0002915844,0.005132515,0.000007130298,0.00001498785,0.001182835,0.00005194301,0.0008736933,0.9826568,0.0006564306,0.009106585,0.00001362748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858378,0.002872216,0.007115856,0.0002284634,0.00004760838,0.00003831045,0.0006917031,0.0001226002,0.003045546],"genre_scores_gemma":[0.9914937,0.000686631,0.005735121,0.00006116131,0.00001417084,0.000009047194,0.0003407814,0.000009119047,0.001650237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001144263,"threshold_uncertainty_score":0.003827929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776540238664756,"score_gpt":0.2638676734589243,"score_spread":0.2461022710722768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}