{"id":"W2515963470","doi":"10.1021/jacs.6b07588","title":"Homodimericin A: A Complex Hexacyclic Fungal Metabolite","year":2016,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health","funders":"National Center for Complementary and Integrative Health; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Chemistry; Stereocenter; Metabolite; Stereochemistry; Bafilomycin; Molecule; Actinobacteria; Secondary metabolite; Organic chemistry; Biochemistry; Enantioselective synthesis; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002639744,0.0001423781,0.0005437084,0.00001673664,0.00005917141,0.00001136852,0.0002812954,0.00004263491,0.00009279138],"category_scores_gemma":[0.0003052505,0.00005589184,0.0008480941,0.0003508623,0.0005608491,0.00006113928,0.0001006155,0.0003176248,0.000009478591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238217,"about_ca_system_score_gemma":0.00007564405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001792612,"about_ca_topic_score_gemma":1.056976e-7,"domain_scores_codex":[0.9988325,0.00005234783,0.0003769936,0.0001482577,0.0003373064,0.0002525504],"domain_scores_gemma":[0.9986964,0.0001289199,0.0005854402,0.0002637436,0.0001767793,0.0001487238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001543729,0.00008471464,0.001927683,0.000009765051,0.0002003769,0.000003362703,0.00004520412,5.748391e-8,0.9452778,0.000007660567,0.0354607,0.0168283],"study_design_scores_gemma":[0.0008780059,0.0001213022,0.02555523,0.00008412083,0.0002846664,0.0005251298,0.00008118764,0.000004338689,0.921437,0.00006834228,0.05083692,0.0001237632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598987,0.0003300373,0.00005490697,0.03938799,0.0001163322,0.00008192076,0.00001022884,0.00001204213,0.0001079147],"genre_scores_gemma":[0.988638,0.0003046112,0.00472843,0.005143746,0.0008037004,1.716226e-7,3.431788e-7,0.00001538077,0.0003655568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03424424,"threshold_uncertainty_score":0.2279203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776540238664756,"score_gpt":0.2638676734589243,"score_spread":0.2461022710722768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}