{"id":"W2515987897","doi":"10.1039/c6md00373g","title":"Chemical probes and inhibitors of bromodomains outside the BET family","year":2016,"lang":"en","type":"review","venue":"MedChemComm","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Burnaby Hospital; Simon Fraser University","funders":"Novartis Pharma; Woolf Fisher Trust; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; University of Cambridge; University of Oxford; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Wellcome; Simon Fraser University; Engineering and Physical Sciences Research Council; AstraZeneca; Pfizer","keywords":"Bromodomain; Acetylation; Epigenetics; Lysine; Computational biology; Chemistry; Biology; Biochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003083319,0.0007549252,0.000867506,0.001620351,0.0002445401,0.0004680183,0.0006767317,0.0007470823,0.003312108],"category_scores_gemma":[0.0003086525,0.0002710396,0.0003551158,0.0009931159,0.000362648,0.0007511514,0.0005421932,0.001541807,0.002644226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004286058,"about_ca_system_score_gemma":0.0003137175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003853907,"about_ca_topic_score_gemma":0.001026236,"domain_scores_codex":[0.9998735,0.00001423712,0.000009011862,0.00002693541,0.00005600282,0.000020179],"domain_scores_gemma":[0.9999032,0.0000368134,0.00002012857,0.000004533165,0.00002113393,0.0000142337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001203211,0.0002028493,0.0001788018,0.01007303,0.00007766376,0.000347742,0.0000804634,0.0008160914,0.02571774,0.00801853,0.02814391,0.9262229],"study_design_scores_gemma":[0.00002815119,0.0001737102,0.0005054779,0.0007080277,0.00004669428,0.001113179,0.0000269261,0.0001440414,0.007165425,0.001407297,0.9886605,0.0000207044],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000808379,0.9942006,0.0006308677,0.0001908201,0.0002516468,0.00001619175,0.00004550054,0.00003306316,0.003822929],"genre_scores_gemma":[0.005826979,0.9883963,0.000611795,0.0003166109,0.0001773031,0.00002903046,0.0001195323,0.000005137606,0.004517325],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003312108,"threshold_uncertainty_score":0.01108009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256940538761223,"score_gpt":0.2918795049121337,"score_spread":0.2693100995245215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}