{"id":"W2516276209","doi":"10.1371/journal.ppat.1005831","title":"Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"Novo Nordisk Fonden; Novo Nordisk; Lunds Universitet; Danmarks Grundforskningsfond; University of Manchester","keywords":"Syncytiotrophoblast; Syndecan 1; Syncytium; Placenta; Plasmodium falciparum; Biology; Cell biology; Malaria; Immunology; Biochemistry; Fetus; Cell; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001624582,0.0001606706,0.000271798,0.00008315953,0.00007186001,0.00001678687,0.00006110617,0.0001223655,0.0002023452],"category_scores_gemma":[0.0001068452,0.00009737547,0.00005791051,0.0001132464,0.00006537138,0.0001032055,0.00002403934,0.0001193277,0.00006060648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000475017,"about_ca_system_score_gemma":0.0000334437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001380782,"about_ca_topic_score_gemma":0.000005434396,"domain_scores_codex":[0.9988552,0.00009439396,0.0003014667,0.0002590345,0.0003037742,0.0001861789],"domain_scores_gemma":[0.999162,0.0002632762,0.0001721523,0.0002202187,0.0000731345,0.0001092645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001648605,0.0001837008,0.04492076,0.00002989101,0.000161409,0.00000438998,0.0002943067,2.898879e-7,0.9518765,0.0007169564,0.0004502739,0.001196646],"study_design_scores_gemma":[0.002114419,0.0007429946,0.1196823,0.0003177474,0.0003410773,0.00002377495,0.0002090466,0.0004058479,0.8753861,0.0003045055,0.000297737,0.0001743938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944161,0.00002556254,0.0002278732,0.003894927,0.00009029699,0.0003985299,0.0004200165,0.00005581131,0.0004708686],"genre_scores_gemma":[0.9991176,0.00005278574,0.0000977359,0.0002946675,0.00006388543,0.0000244361,0.0001336141,0.00002277745,0.00019257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0764904,"threshold_uncertainty_score":0.3970856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03765811053828788,"score_gpt":0.2797705763655438,"score_spread":0.2421124658272559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}