{"id":"W2516276209","doi":"10.1371/journal.ppat.1005831","title":"Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"Novo Nordisk Fonden; Novo Nordisk; Lunds Universitet; Danmarks Grundforskningsfond; University of Manchester","keywords":"Syncytiotrophoblast; Syndecan 1; Syncytium; Placenta; Plasmodium falciparum; Biology; Cell biology; Malaria; Immunology; Biochemistry; Fetus; Cell; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001035037,0.0002411893,0.0001513233,0.0001565098,0.0001649758,0.0002235259,0.0001719476,0.0001573911,0.001317043],"category_scores_gemma":[0.0001335558,0.0001544965,0.0001944012,0.0001326055,0.0001142681,0.0001132374,0.0002623591,0.0003044034,0.0003425704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002740392,"about_ca_system_score_gemma":0.0001642863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002006216,"about_ca_topic_score_gemma":0.002392848,"domain_scores_codex":[0.9998314,0.00004132107,0.00001206249,0.00002809989,0.00004537716,0.00004170684],"domain_scores_gemma":[0.9999465,0.000008626296,0.0000144018,0.00000645254,0.000008065605,0.00001595189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004759126,0.000007757177,0.0003655842,0.00002281353,0.000003855199,0.00007204359,0.00001385742,0.00002425444,0.9988253,0.00006484224,0.00003874936,0.0005134207],"study_design_scores_gemma":[0.00001524236,0.0003065123,0.04416782,0.00001501723,0.00002754656,0.001110326,0.0001276598,0.003003447,0.9454296,0.00007634164,0.005711724,0.000008841721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949785,0.001550394,0.00173073,0.0001112794,0.000014004,0.00001423209,0.0002072758,0.00004012439,0.00135349],"genre_scores_gemma":[0.9966091,0.0005865882,0.0008608402,0.00004179253,0.000004758025,0.00001220083,0.000264856,0.000006728351,0.001613189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006216,"threshold_uncertainty_score":0.004405975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03765811053828788,"score_gpt":0.2797705763655438,"score_spread":0.2421124658272559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}