{"id":"W2516402455","doi":"10.1038/ncomms12638","title":"RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; York University; University of Toronto; Ontario Institute for Cancer Research","funders":"Cancer Research UK; Canadian Institutes of Health Research; Moffitt Cancer Center","keywords":"Ubiquitin; Ubiquitin ligase; Chromatin; DNA damage; Cancer research; Biology; Cell biology; Topoisomerase; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186377,0.0001033145,0.00007592592,0.00004305122,0.0001950687,0.00002063801,0.0001996348,0.000239276,0.000006517524],"category_scores_gemma":[0.00003910007,0.00008114507,0.00003923522,0.00006654553,0.00003638094,0.000007603392,0.000142292,0.0001582457,0.000006703637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002503852,"about_ca_system_score_gemma":0.0000212686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002664913,"about_ca_topic_score_gemma":0.00006344489,"domain_scores_codex":[0.9994314,0.00007881253,0.0001023583,0.0001937892,0.00007706825,0.0001165406],"domain_scores_gemma":[0.9989526,0.0000539545,0.00006294677,0.0007921577,0.00008475704,0.00005359833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007552325,0.00002718154,0.00005106183,0.000005901778,0.00002904681,1.305516e-7,0.00001426724,9.676133e-7,0.9025291,0.00473345,0.0002565568,0.09227677],"study_design_scores_gemma":[0.0008538542,0.000473839,0.005191761,0.00007174344,0.00005457456,0.000008238495,0.000007817514,0.0001143422,0.8246726,0.001728725,0.166604,0.0002184485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9520221,0.01946267,0.01241551,0.01226056,0.0008320327,0.0007346172,0.00004218306,0.00007578675,0.002154479],"genre_scores_gemma":[0.9957615,0.00187267,0.0005268763,0.001159523,0.0001258973,0.00002990122,0.00007178973,0.00001699405,0.000434867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1663475,"threshold_uncertainty_score":0.3309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01665146740151329,"score_gpt":0.2887422474786615,"score_spread":0.2720907800771482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}