{"id":"W2516402455","doi":"10.1038/ncomms12638","title":"RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; York University; University of Toronto; Ontario Institute for Cancer Research","funders":"Cancer Research UK; Canadian Institutes of Health Research; Moffitt Cancer Center","keywords":"Ubiquitin; Ubiquitin ligase; Chromatin; DNA damage; Cancer research; Biology; Cell biology; Topoisomerase; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002351253,0.0003491472,0.0002583436,0.0001907575,0.0001221951,0.0004300175,0.0001862606,0.0002863079,0.001133164],"category_scores_gemma":[0.0001658858,0.0001810559,0.0002541651,0.00007690885,0.0002426346,0.000227302,0.0002513547,0.0002696719,0.0003354418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003637978,"about_ca_system_score_gemma":0.0001860093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000372855,"about_ca_topic_score_gemma":0.0005330828,"domain_scores_codex":[0.9997707,0.00005096131,0.00002249757,0.00004054088,0.00006323708,0.00005204638],"domain_scores_gemma":[0.9998511,0.00002030799,0.00004694742,0.00001337672,0.00002025861,0.00004796052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002773678,0.00001146256,0.0003467341,0.00003625894,0.000007836456,0.00008621124,0.000008946287,0.00003465552,0.997407,0.0001367921,0.00003258573,0.001614148],"study_design_scores_gemma":[0.00003189871,0.0002680193,0.006990275,0.000006315473,0.00001639219,0.0007578348,0.00004141036,0.0006017518,0.9881325,0.00009995895,0.003047311,0.000006330729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907578,0.004883361,0.001872185,0.0001443112,0.00004040167,0.00001838291,0.0002025047,0.00008829074,0.001992717],"genre_scores_gemma":[0.9959907,0.001013188,0.001189846,0.00004121022,0.000009594542,0.00001564729,0.0001557635,0.00001248653,0.001571687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001133164,"threshold_uncertainty_score":0.003790855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01665146740151329,"score_gpt":0.2887422474786615,"score_spread":0.2720907800771482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}