{"id":"W2516517589","doi":"10.1186/s13148-016-0253-y","title":"Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells","year":2016,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Diamantina Institute, University of Queensland; Trish Multiple Sclerosis Research Foundation; Canadian Institutes of Health Research; University of Queensland; Multiple Sclerosis Australia","keywords":"Human genetics; microRNA; Multiple sclerosis; Biology; Computational biology; Genetics; Medicine; Bioinformatics; Gene; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002686506,0.0002173506,0.0002781269,0.0003180117,0.0001829762,0.0003768286,0.0001161999,0.0002976742,0.001474437],"category_scores_gemma":[0.0004406033,0.0001340075,0.0003015838,0.0002171314,0.0001601819,0.0001014304,0.000186559,0.0003188186,0.0004589186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001858162,"about_ca_system_score_gemma":0.0001513135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003681784,"about_ca_topic_score_gemma":0.000809582,"domain_scores_codex":[0.9997452,0.00002744981,0.00002244021,0.00009756475,0.00007237299,0.00003504204],"domain_scores_gemma":[0.9998266,0.00004394986,0.00004517905,0.00001756685,0.00004630857,0.00002037834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003759089,0.00002235621,0.01154635,0.00009034815,0.0000461502,0.00008160765,0.0000757541,0.0001518065,0.9789801,0.00004000963,0.0002265926,0.008363176],"study_design_scores_gemma":[0.00006141865,0.0009854604,0.3690436,0.00004205038,0.0002348993,0.001558459,0.0002396978,0.003818211,0.616934,0.0003336656,0.006724722,0.00002390563],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922957,0.001086028,0.003983697,0.0000676092,0.00002736634,0.00002671711,0.001350856,0.0001043688,0.001057634],"genre_scores_gemma":[0.9884136,0.0004489285,0.007200581,0.0001946176,0.0000213903,0.0001046432,0.00199592,0.00004528926,0.00157505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001474437,"threshold_uncertainty_score":0.004932523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2068559815960139,"score_gpt":0.349268747507373,"score_spread":0.1424127659113591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}