{"id":"W2516960518","doi":"10.1038/ni.3538","title":"NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations","year":2016,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Ono Pharmaceutical","keywords":"Inflammasome; Pyroptosis; Cell biology; Phosphorylation; Inflammation; Receptor; Signal transduction; Biology; Mutant; Prostaglandin E2 receptor; Caspase 1; Kinase; Prostanoid; Chemistry; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002401192,0.001230667,0.000425763,0.001006466,0.0006256009,0.0004427005,0.0005057532,0.001165679,0.003571274],"category_scores_gemma":[0.0007877669,0.0002301777,0.0006828201,0.0005858392,0.001002234,0.0002827114,0.0007550037,0.0007211551,0.0004434071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003068972,"about_ca_system_score_gemma":0.0003188502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0014307,"about_ca_topic_score_gemma":0.001290016,"domain_scores_codex":[0.9995682,0.00007268794,0.00007755699,0.0001055657,0.00008804566,0.00008797716],"domain_scores_gemma":[0.9993497,0.0001461159,0.0002593235,0.00005371267,0.0000471375,0.0001439579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001447415,0.000235315,0.009572883,0.000191338,0.0003017478,0.0495898,0.0003754899,0.001173713,0.9254365,0.001264369,0.001021323,0.009390126],"study_design_scores_gemma":[0.0005986965,0.002333045,0.2389039,0.0001585369,0.0009214729,0.2295981,0.0008771576,0.006492266,0.5032241,0.001857408,0.01484956,0.0001857301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949535,0.0005407337,0.001500359,0.000193919,0.00006787211,0.00003750771,0.0008649832,0.0001162121,0.001724898],"genre_scores_gemma":[0.9978344,0.0001900007,0.0008483601,0.00009777889,0.00003113721,0.00001863074,0.0003030255,0.00005670694,0.0006199461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003571274,"threshold_uncertainty_score":0.0119471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002602119119319785,"score_gpt":0.2196036241636302,"score_spread":0.2170015050443104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}