{"id":"W2516960518","doi":"10.1038/ni.3538","title":"NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations","year":2016,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Ono Pharmaceutical","keywords":"Inflammasome; Pyroptosis; Cell biology; Phosphorylation; Inflammation; Receptor; Signal transduction; Biology; Mutant; Prostaglandin E2 receptor; Caspase 1; Kinase; Prostanoid; Chemistry; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409954,0.0002044803,0.0002128016,0.0002092697,0.000054738,0.000006626035,0.0001896026,0.0005759174,0.00008400287],"category_scores_gemma":[0.0002440757,0.0001664425,0.0001372623,0.0001853935,0.0002738264,0.00001982088,0.0001214036,0.0002687363,0.00003017445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003548793,"about_ca_system_score_gemma":0.0001214324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001281548,"about_ca_topic_score_gemma":0.00006480024,"domain_scores_codex":[0.9986703,0.0001092952,0.0004097165,0.0003590746,0.00011765,0.0003339852],"domain_scores_gemma":[0.9991554,0.00002950967,0.0001684785,0.0004732134,0.0001256685,0.00004774569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004048106,0.0001042907,0.01094847,0.00002469244,0.00008083165,0.00002052555,0.0001199223,0.000002881387,0.9829454,0.001331197,0.0003398012,0.003677205],"study_design_scores_gemma":[0.004454339,0.0003674323,0.4119548,0.0001489513,0.0000446538,0.00001697279,0.0001929673,0.00001323362,0.5423045,0.002243,0.03773517,0.0005239689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937059,0.004293156,0.0001131915,0.000871095,0.0002640049,0.0002589492,0.00006578421,0.00002203802,0.0004059242],"genre_scores_gemma":[0.9983509,0.0005071773,0.00006017468,0.0002600057,0.00006779543,0.00006619067,0.0002789882,0.00002737447,0.0003813597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4406409,"threshold_uncertainty_score":0.6787327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002602119119319785,"score_gpt":0.2196036241636302,"score_spread":0.2170015050443104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}