{"id":"W2517200974","doi":"10.1083/jcb.201512077","title":"TMX1 determines cancer cell metabolism as a thiol-based modulator of ER–mitochondria Ca2+ flux","year":2016,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Heritage Foundation for Medical Research; Canada Foundation for Innovation; Canadian Cancer Society; Alberta Innovates - Health Solutions; Canadian Cancer Society Research Institute; Cancer Research Society; Heart and Stroke Foundation of Canada","keywords":"Mitochondrion; Biology; Endoplasmic reticulum; Cell biology; Cytosol; Intracellular; Apoptosis; Cancer cell; Voltage-dependent anion channel; Biochemistry; Bacterial outer membrane; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003765115,0.0001987504,0.0003850999,0.00006617021,0.00005598494,0.000004423965,0.000433172,0.0002858689,0.0005496748],"category_scores_gemma":[0.0001320689,0.0001015764,0.0002324218,0.00006767977,0.0002135495,0.000006504303,0.00007178767,0.000127223,0.00002321592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001698574,"about_ca_system_score_gemma":0.000302569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006679961,"about_ca_topic_score_gemma":0.00006091984,"domain_scores_codex":[0.998476,0.0004302078,0.000531837,0.0001901615,0.0001067423,0.0002650757],"domain_scores_gemma":[0.9984246,0.0001267961,0.0006286521,0.0003875823,0.0003266209,0.0001056983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008184428,0.00005868169,0.0002624379,0.00001250375,0.00004708738,0.000002934196,0.00004306011,0.00004054572,0.995486,0.00004445009,0.001808867,0.001375055],"study_design_scores_gemma":[0.001540942,0.0007683769,0.0001720195,0.00001500807,0.0001020572,0.00005099287,0.00002657504,0.00001088879,0.9214883,0.0002097008,0.07548627,0.0001288321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867553,0.004243497,0.004735311,0.0003886811,0.00214746,0.0001511687,0.00003893756,0.000004887219,0.001534781],"genre_scores_gemma":[0.9932186,0.001336652,0.0009738874,0.00070338,0.000990869,0.000007267829,0.00000808388,0.00002326817,0.002737965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0739976,"threshold_uncertainty_score":0.6018554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00989597508565859,"score_gpt":0.2515893371525566,"score_spread":0.241693362066898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}