{"id":"W2517200974","doi":"10.1083/jcb.201512077","title":"TMX1 determines cancer cell metabolism as a thiol-based modulator of ER–mitochondria Ca2+ flux","year":2016,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Heritage Foundation for Medical Research; Canada Foundation for Innovation; Canadian Cancer Society; Alberta Innovates - Health Solutions; Canadian Cancer Society Research Institute; Cancer Research Society; Heart and Stroke Foundation of Canada","keywords":"Mitochondrion; Biology; Endoplasmic reticulum; Cell biology; Cytosol; Intracellular; Apoptosis; Cancer cell; Voltage-dependent anion channel; Biochemistry; Bacterial outer membrane; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000919446,0.0001890131,0.0002550952,0.0002179414,0.0002368736,0.0004393114,0.0001537558,0.0003377345,0.001208611],"category_scores_gemma":[0.0001192741,0.0001445438,0.0001417115,0.0002141132,0.0002079392,0.0002233942,0.0002100132,0.0003372435,0.0003552254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004312055,"about_ca_system_score_gemma":0.0001459171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005880892,"about_ca_topic_score_gemma":0.0007636881,"domain_scores_codex":[0.9999237,0.00001122795,0.000005062002,0.00002349197,0.00001631814,0.00002018155],"domain_scores_gemma":[0.9999212,0.00001360866,0.00002064639,0.000008036733,0.00001343645,0.00002304835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001095622,0.000008784055,0.0007668987,0.00001199289,0.000002111648,0.0000342136,0.00001499643,0.00004836897,0.9983126,0.00008705875,0.00002540992,0.0005778979],"study_design_scores_gemma":[0.00001821023,0.0001552502,0.03876727,0.00000520937,0.00001786657,0.0003497152,0.00008824713,0.001649794,0.9568346,0.0001696923,0.001936152,0.000007915504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996276,0.00139758,0.001123675,0.0001277646,0.00001095614,0.00001157506,0.0002332366,0.00004601347,0.0007733108],"genre_scores_gemma":[0.9976628,0.0004780234,0.0004104112,0.00002503071,0.000003367937,0.00000996559,0.0002798403,0.000008316515,0.001122192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001208611,"threshold_uncertainty_score":0.004043162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00989597508565859,"score_gpt":0.2515893371525566,"score_spread":0.241693362066898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}