{"id":"W2517219039","doi":"10.1021/acsnano.6b04663","title":"Semisynthetic Nanoreactor for Reversible Single-Molecule Covalent Chemistry","year":2016,"lang":"en","type":"article","venue":"ACS Nano","topic":"Nanopore and Nanochannel Transport Studies","field":"Engineering","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"European Research Council; Christ's College, University of Cambridge","keywords":"Nanoreactor; Covalent bond; Chemistry; Molecule; Side chain; Monomer; Dynamic covalent chemistry; Combinatorial chemistry; Cysteine; Amino acid; Organic chemistry; Polymer; Biochemistry; Supramolecular chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006967149,0.0001919923,0.0002108775,0.0000335907,0.00007096123,0.000009147579,0.0001549225,0.00009908759,0.00008892343],"category_scores_gemma":[0.00003069089,0.0001431572,0.0001083147,0.0001085829,0.00004592324,0.00007889129,0.00001916819,0.0000379129,0.00004687548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007854861,"about_ca_system_score_gemma":0.00001588854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002143521,"about_ca_topic_score_gemma":0.000002603129,"domain_scores_codex":[0.9991068,0.00000361527,0.0001978163,0.0002132115,0.0001211154,0.0003574353],"domain_scores_gemma":[0.9995042,0.000088322,0.000029286,0.0002486278,0.00005651588,0.00007303971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001258727,0.00003253861,0.0001188029,0.0001535522,0.00006358878,0.000004264335,0.00006759891,0.000009734379,0.9884916,0.00002192341,0.009306022,0.001717812],"study_design_scores_gemma":[0.0005652883,0.00003811844,0.00002672686,0.0001204099,0.0000380729,0.000004864305,0.00001789238,0.00000819303,0.895754,0.0001060044,0.1030942,0.000226157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975405,0.002661908,0.00880164,0.0006447856,0.0008889074,0.0005483825,0.0002636491,0.0007837412,0.01000199],"genre_scores_gemma":[0.9950399,0.0004135304,0.0003284645,0.00003771426,0.0001369364,0.00006631576,0.00001365822,0.00005209996,0.003911336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09378822,"threshold_uncertainty_score":0.583778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315076863984386,"score_gpt":0.1955314482043092,"score_spread":0.1823806795644654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}