{"id":"W2517222404","doi":"10.1038/srep28902","title":"ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Fondation pour la Recherche Médicale","keywords":"MHC class I; Major histocompatibility complex; Peptide; Antigen presentation; Antigen processing; Transporter associated with antigen processing; Context (archaeology); Biology; MHC restriction; Cell biology; Antigen; Chemistry; Computational biology; Biochemistry; Immune system; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003721533,0.0003281344,0.0002350045,0.0001149441,0.0001887292,0.0005138867,0.0003694204,0.000518884,0.001100801],"category_scores_gemma":[0.0003359637,0.000188503,0.0001931299,0.000108632,0.000314103,0.00107477,0.0002151255,0.0007352354,0.0004686871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000232927,"about_ca_system_score_gemma":0.0001201922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007709198,"about_ca_topic_score_gemma":0.00009622419,"domain_scores_codex":[0.999904,0.00002033025,0.00000741693,0.00003739872,0.0000167041,0.00001410127],"domain_scores_gemma":[0.999831,0.00004547375,0.0000566235,0.0000287615,0.00001395254,0.00002418661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001546475,0.00003392413,0.0009046305,0.0001379168,0.00001242491,0.000335238,0.00008281635,0.0007858797,0.9901901,0.002136958,0.0002181051,0.005007435],"study_design_scores_gemma":[0.00003402078,0.0002395882,0.008661567,0.0000256223,0.00004019407,0.002719338,0.0002098524,0.01170462,0.9594214,0.00371026,0.01320402,0.0000296861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9434675,0.0197811,0.03093361,0.001209264,0.0001285126,0.0000252976,0.0003211835,0.0001882952,0.003945174],"genre_scores_gemma":[0.9837607,0.00342694,0.01008812,0.0002254549,0.00006789608,0.0000208065,0.0002137316,0.00003642834,0.002159919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100801,"threshold_uncertainty_score":0.003682554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03590049484175901,"score_gpt":0.2720528195344458,"score_spread":0.2361523246926868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}