{"id":"W2517222404","doi":"10.1038/srep28902","title":"ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Fondation pour la Recherche Médicale","keywords":"MHC class I; Major histocompatibility complex; Peptide; Antigen presentation; Antigen processing; Transporter associated with antigen processing; Context (archaeology); Biology; MHC restriction; Cell biology; Antigen; Chemistry; Computational biology; Biochemistry; Immune system; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001695684,0.0002591889,0.0003108837,0.000277066,0.001961329,0.0001764591,0.0002976338,0.0001927003,0.0002303679],"category_scores_gemma":[0.0005503976,0.0001952992,0.0002896034,0.0004221332,0.0009845039,0.0003913157,0.00008415744,0.0001549895,0.0001383229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001513704,"about_ca_system_score_gemma":0.0002638904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002482103,"about_ca_topic_score_gemma":0.0000109334,"domain_scores_codex":[0.9972745,0.0000890385,0.0007630931,0.0009688188,0.00008895409,0.0008155525],"domain_scores_gemma":[0.9979948,0.0003248061,0.0005272583,0.0009380447,0.0001921408,0.00002298967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004755096,0.0001566137,0.002168191,0.0000336278,0.0001312278,0.000004519817,0.0008832305,0.000008072951,0.9511228,0.007726704,0.02708555,0.01063193],"study_design_scores_gemma":[0.002469504,0.0002024641,0.006076579,0.0004002737,0.0001684928,0.0005124627,0.003108022,0.000005821095,0.1333859,0.146438,0.7062647,0.0009678524],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8226435,0.02131166,0.07203893,0.007819848,0.0564126,0.003590027,0.0001433426,0.000851729,0.01518841],"genre_scores_gemma":[0.9749025,0.00001992003,0.00009166171,0.00006813763,0.00002347565,0.0001662028,0.0001746335,0.00003216317,0.02452133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8177369,"threshold_uncertainty_score":0.999338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03590049484175901,"score_gpt":0.2720528195344458,"score_spread":0.2361523246926868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}