{"id":"W2517286712","doi":"10.1002/cpnc.14","title":"Preparation of Intrastrand {G}<i>O</i><sup>6</sup>‐Alkylene‐<i>O</i><sup>6</sup>{G} Cross‐Linked Oligonucleotides","year":2016,"lang":"en","type":"article","venue":"Current Protocols in Nucleic Acid Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Oligonucleotide; Phosphodiester bond; Deoxyguanosine; Chemistry; Dimer; DNA; Polynucleotide; Stereochemistry; Guanosine; Oligonucleotide synthesis; Reagent; Solid-phase synthesis; Cleavage (geology); Nucleotide; Combinatorial chemistry; Organic chemistry; Biochemistry; RNA; Peptide; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001666379,0.0003611982,0.0002415624,0.0001723828,0.0001674012,0.00017914,0.0003014058,0.0002516228,0.00268761],"category_scores_gemma":[0.0001938149,0.0002079957,0.0001826891,0.0001953809,0.00009222965,0.0001839046,0.0001979245,0.0004926341,0.001604249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001421919,"about_ca_system_score_gemma":0.0001930128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001237607,"about_ca_topic_score_gemma":0.0003119587,"domain_scores_codex":[0.9999158,0.00001077138,0.000006712857,0.00002583294,0.00002527715,0.00001561344],"domain_scores_gemma":[0.9999028,0.00001352658,0.0000251825,0.00001847536,0.00002115219,0.00001885793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001904562,0.0000100645,0.00006228565,0.00003993382,0.000002584107,0.00002304455,0.00001781966,0.0001183495,0.9956534,0.0001573197,0.00006629425,0.003829906],"study_design_scores_gemma":[0.000004467785,0.000113318,0.000244058,0.000003556127,0.000004968798,0.00005879016,0.000007171108,0.0001462017,0.9940451,0.00004264584,0.005326095,0.000003633472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8919818,0.002909082,0.08915764,0.0001331144,0.0001627284,0.0005221521,0.001519137,0.0007768418,0.0128375],"genre_scores_gemma":[0.8514178,0.005550101,0.1152238,0.0001566142,0.00005684579,0.0005128911,0.0055205,0.0003352711,0.0212263],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00268761,"threshold_uncertainty_score":0.008990943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01461201700437851,"score_gpt":0.3170689399949829,"score_spread":0.3024569229906044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}