{"id":"W2517466029","doi":"10.15252/embr.201642771","title":"Natural mutations in IFITM3 modulate post‐translational regulation and toggle antiviral specificity","year":2016,"lang":"en","type":"article","venue":"EMBO Reports","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Agence Nationale de la Recherche; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; National Cancer Institute; Sidaction; Styrelsen för Internationellt Utvecklingssamarbete; Pasteur Foundation","keywords":"Biology; Gene duplication; Antiviral protein; Gene; Virus; Viral envelope; Virology; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001895475,0.0002805309,0.0001758391,0.0001284903,0.0002147071,0.0003255668,0.0002955852,0.0004841723,0.002919706],"category_scores_gemma":[0.0003118927,0.000131435,0.0002883867,0.00009246124,0.0004489911,0.0002336947,0.0002879751,0.0008958965,0.0007780293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003961174,"about_ca_system_score_gemma":0.0002117517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003861965,"about_ca_topic_score_gemma":0.0007329356,"domain_scores_codex":[0.9998472,0.00003313619,0.00001717372,0.00002823977,0.00002845514,0.00004574425],"domain_scores_gemma":[0.9997677,0.00005490607,0.0000827115,0.0000337001,0.00001247131,0.00004841259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002100543,0.00001980118,0.0002060249,0.00001060171,0.000005584727,0.00006399871,0.000007403819,0.00009488282,0.9984041,0.0002122302,0.00006471681,0.0007006424],"study_design_scores_gemma":[0.00007065164,0.0001223393,0.004142455,0.000006902075,0.00001482895,0.0004495211,0.00003354415,0.002367989,0.9907312,0.0003028273,0.001744041,0.00001381754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967655,0.0004173788,0.001288727,0.0001699312,0.00005860139,0.00001332669,0.0001829559,0.0001033761,0.001000236],"genre_scores_gemma":[0.9987497,0.0000735391,0.0005182,0.0000609382,0.000006427656,0.00001050372,0.0000915393,0.00003269252,0.0004564833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002919706,"threshold_uncertainty_score":0.009767354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009172336184389474,"score_gpt":0.2379033209609388,"score_spread":0.2287309847765494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}