{"id":"W2517637924","doi":"10.1038/srep32583","title":"Integration of transcriptomic and genomic data suggests candidate mechanisms for APOE4-mediated pathogenic action in Alzheimer’s disease","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Genentech; National Institutes of Health; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; CurePSP; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Mayo Foundation for Medical Education and Research; F. Hoffmann-La Roche; University of Southern California; Mayo Clinic; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Novartis Pharmaceuticals Corporation; Arizona Department of Health Services; Michael J. Fox Foundation for Parkinson's Research; Arizona Biomedical Research Commission; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Transcriptome; Disease; Action (physics); Alzheimer's disease; Computational biology; Biology; Bioinformatics; Genetics; Gene; Medicine; Gene expression; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004712179,0.000248103,0.0002877759,0.001246919,0.0001689078,0.0005021603,0.000142949,0.0001825729,0.0007627454],"category_scores_gemma":[0.0006313903,0.0001145023,0.0003082828,0.0007797453,0.0002552078,0.0003496741,0.000212258,0.0002117953,0.00009315757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002929321,"about_ca_system_score_gemma":0.000339668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008971137,"about_ca_topic_score_gemma":0.001007043,"domain_scores_codex":[0.9998143,0.00005056968,0.00001501608,0.00005783888,0.00003617769,0.00002598226],"domain_scores_gemma":[0.9996477,0.0001440473,0.0001069029,0.00003022392,0.00004121329,0.00002984289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001619894,0.0002259568,0.2313854,0.0004461129,0.0005012581,0.0009201404,0.0002715938,0.007972574,0.6977829,0.004800506,0.0003092203,0.05376462],"study_design_scores_gemma":[0.00004559325,0.0005455302,0.8590754,0.00008113882,0.000718749,0.00124243,0.0006367108,0.04135005,0.07241078,0.02043854,0.003397671,0.0000574881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726368,0.001896581,0.02262633,0.0003591061,0.00001435853,0.00002151944,0.001194593,0.00009193434,0.00115873],"genre_scores_gemma":[0.9899172,0.000879007,0.007784311,0.00006749373,0.00001131811,0.00001506293,0.00106521,0.000007525991,0.0002529235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246919,"threshold_uncertainty_score":0.002551615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05607499867318535,"score_gpt":0.3093007721033619,"score_spread":0.2532257734301765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}