{"id":"W2517659650","doi":"10.1534/g3.116.034264","title":"A Forward Genetic Screen and Whole Genome Sequencing Identify Deflagellation Defective Mutants in<i>Chlamydomonas</i>, Including Assignment of ADF1 as a TRP Channel","year":2016,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chlamydomonas; Biology; Basal body; Genetics; Centrosome; Cilium; Gene; Genetic screen; Microtubule; Cell biology; Mutagenesis; Mutant; Flagellum; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660554,0.0008361872,0.0003330825,0.0004757826,0.0003081938,0.0002998346,0.0004383138,0.0005095406,0.000858577],"category_scores_gemma":[0.0002611458,0.0001944027,0.0005644684,0.0002874271,0.0003074935,0.000109013,0.000385862,0.0006921075,0.0003338321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006683449,"about_ca_system_score_gemma":0.0006805031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008149724,"about_ca_topic_score_gemma":0.01569702,"domain_scores_codex":[0.9997475,0.00001223423,0.00002390135,0.00007216501,0.00009575978,0.00004849423],"domain_scores_gemma":[0.9997272,0.00008725905,0.00005933725,0.0000293616,0.00003320465,0.00006357331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002054501,0.00002512074,0.0005419402,0.00002098965,0.00000611638,0.0001457252,0.00001593085,0.00005397318,0.9976656,0.00004593896,0.00005431346,0.001403876],"study_design_scores_gemma":[0.0000201756,0.0002428311,0.02878385,0.00001407253,0.00006924489,0.001517616,0.00007197294,0.001333036,0.963814,0.0000487457,0.004059011,0.0000253559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971347,0.0007087908,0.02041611,0.0003165311,0.00008205937,0.0001998306,0.004386064,0.000615612,0.001927994],"genre_scores_gemma":[0.9554367,0.0008913418,0.03291795,0.0003475726,0.00001079222,0.0001435027,0.005075856,0.0001890383,0.004987176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008149724,"threshold_uncertainty_score":0.01620454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01805905007838191,"score_gpt":0.2658403881486996,"score_spread":0.2477813380703177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}