{"id":"W2517659650","doi":"10.1534/g3.116.034264","title":"A Forward Genetic Screen and Whole Genome Sequencing Identify Deflagellation Defective Mutants in<i>Chlamydomonas</i>, Including Assignment of ADF1 as a TRP Channel","year":2016,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chlamydomonas; Biology; Basal body; Genetics; Centrosome; Cilium; Gene; Genetic screen; Microtubule; Cell biology; Mutagenesis; Mutant; Flagellum; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002990152,0.0004314356,0.000441192,0.000237534,0.0001325257,0.00003921715,0.0003351583,0.0002714148,0.00002759201],"category_scores_gemma":[0.00004036057,0.0003833545,0.0001684315,0.0002375571,0.0002226729,0.00001266314,0.0004737489,0.0000744307,0.00002240843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123488,"about_ca_system_score_gemma":0.0003321363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005287039,"about_ca_topic_score_gemma":0.00008684492,"domain_scores_codex":[0.9972929,0.0001727592,0.0006755379,0.0008507913,0.0003745618,0.0006334824],"domain_scores_gemma":[0.9985557,0.00004577704,0.0003103818,0.0005889452,0.0001809888,0.0003182378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001156904,0.00005583362,0.02374907,0.00006929894,0.0001271739,0.00001504992,0.0003209908,0.001281449,0.8988823,0.000004132244,0.0000189089,0.0753601],"study_design_scores_gemma":[0.004450525,0.001513663,0.1493963,0.0002424582,0.0003278847,0.000148892,0.001247861,0.0004682634,0.8254078,0.002446227,0.01288875,0.001461403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8444906,0.1458348,0.008357717,0.00006441461,0.0001123215,0.0006420786,0.0002229419,0.00001615796,0.000259012],"genre_scores_gemma":[0.9614018,0.0356635,0.002121788,0.0001405264,0.0002101452,0.00006896821,0.00008185508,0.00007552928,0.000235859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1256472,"threshold_uncertainty_score":0.9998618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01805905007838191,"score_gpt":0.2658403881486996,"score_spread":0.2477813380703177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}