{"id":"W2517715384","doi":"10.1093/infdis/jiw410","title":"Azithromycin and Doxycycline Attenuation of<i>Acanthamoeba</i>Virulence in a Human Corneal Tissue Model","year":2016,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Public Health Ontario; Toronto General Hospital; Toronto Public Health; University of British Columbia","funders":"","keywords":"Acanthamoeba; Microbiology; Biology; Virulence; Acanthamoeba keratitis; Doxycycline; Keratitis; Azithromycin; Chlamydia trachomatis; Virology; Antibiotics; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322054,0.0002536756,0.0002670204,0.000172898,0.0001088835,0.0001800726,0.0001572879,0.0002061145,0.001401545],"category_scores_gemma":[0.0001090452,0.00008242293,0.0002624684,0.0001329173,0.0001564232,0.0001347274,0.0001584179,0.000402188,0.0002485799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002061705,"about_ca_system_score_gemma":0.0002574486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001783502,"about_ca_topic_score_gemma":0.002583462,"domain_scores_codex":[0.9998266,0.00003348392,0.00002238971,0.00002962355,0.00003642224,0.00005143701],"domain_scores_gemma":[0.9998956,0.00002376729,0.00002384405,0.00001540357,0.00001750337,0.00002393361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006072613,0.000182794,0.0003744923,0.00008636749,0.000008025158,0.00008071738,0.00002227895,0.00007322298,0.9966508,0.00002143844,0.00008325461,0.001809455],"study_design_scores_gemma":[0.00006263193,0.005273499,0.01165491,0.00001425892,0.00003075116,0.0002863437,0.00007848106,0.001100717,0.9795262,0.00001700088,0.001948617,0.000006781915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957236,0.001431083,0.0007327825,0.00006888891,0.00004122271,0.00008531295,0.0004245821,0.00005331217,0.001439249],"genre_scores_gemma":[0.9956684,0.0007185074,0.001462845,0.00004661515,0.00000972642,0.00005831179,0.0005930793,0.000006186889,0.001436326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001783502,"threshold_uncertainty_score":0.004688621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01156584228205702,"score_gpt":0.286739946103869,"score_spread":0.275174103821812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}