{"id":"W2517789286","doi":"10.1242/dmm.026773","title":"Upregulation of the <i>Nr2f1</i>-<i>A830082K12Rik</i> gene pair in murine neural crest cells results in a complex phenotype reminiscent of Waardenburg syndrome type 4","year":2016,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Congenital gastrointestinal and neural anomalies","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Université du Québec à Montréal; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fondation du Grand défi Pierre Lavoie","keywords":"Waardenburg syndrome; Neural crest; Biology; Microphthalmia-associated transcription factor; SOX10; Genetics; Phenotype; Insertional mutagenesis; Gene; Transcription factor; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001393384,0.0005381115,0.000326353,0.0003519229,0.000221583,0.0002135511,0.000459998,0.0004476208,0.002201752],"category_scores_gemma":[0.000135301,0.0002353826,0.0002899474,0.0001497478,0.0003948817,0.0001339792,0.000312028,0.0006949006,0.0007844989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003924806,"about_ca_system_score_gemma":0.0002461932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007233835,"about_ca_topic_score_gemma":0.001989751,"domain_scores_codex":[0.9996712,0.00005209384,0.00003724218,0.00007897813,0.0001038102,0.00005661494],"domain_scores_gemma":[0.9998304,0.00002252575,0.00007262309,0.00002227239,0.000007652826,0.00004457526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003282485,0.00001263623,0.00006704882,0.000009940335,0.000002515013,0.00005134789,0.000005176244,0.00003540888,0.9993095,0.0000775435,0.00001553777,0.000380444],"study_design_scores_gemma":[0.00003838619,0.0002886781,0.003736398,0.000007795215,0.00001774784,0.0005956113,0.00002466786,0.0009152704,0.9919225,0.00004992605,0.002395349,0.000007717296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923529,0.0003659231,0.004506328,0.00008529247,0.00003627019,0.00006006171,0.000393822,0.0002239767,0.001975488],"genre_scores_gemma":[0.9863174,0.0002491664,0.007942089,0.00007971581,0.00001053487,0.0001078144,0.0005865369,0.0001089741,0.004597678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002201752,"threshold_uncertainty_score":0.007365644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03532348155888601,"score_gpt":0.2332298987439883,"score_spread":0.1979064171851023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}