{"id":"W2517858742","doi":"10.1371/journal.pntd.0004929","title":"The Effects of Ivermectin on Brugia malayi Females In Vitro: A Transcriptomic Approach","year":2016,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Fonds Québécois de la Recherche sur la Nature et les Technologies; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Science Foundation","keywords":"Ivermectin; Brugia malayi; Lymphatic filariasis; Biology; Onchocerciasis; Onchocerca volvulus; Transcriptome; Onchocerca; Filariasis; Andrology; Gene; Immunology; Genetics; Gene expression; Helminths; Zoology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013717,0.0003923263,0.0003926322,0.0003364752,0.0002123082,0.0002944194,0.0001461994,0.000260783,0.0008559484],"category_scores_gemma":[0.0001348605,0.0001288041,0.0004060657,0.000389333,0.0002361365,0.0001616003,0.0001764493,0.0004914798,0.0003534615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002432864,"about_ca_system_score_gemma":0.0001972563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007475652,"about_ca_topic_score_gemma":0.001865751,"domain_scores_codex":[0.9998932,0.00001080076,0.000007666252,0.0000322946,0.00003415325,0.00002187163],"domain_scores_gemma":[0.9999053,0.00002548281,0.00002617913,0.000006410109,0.00002613735,0.00001042035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004002918,0.000008150675,0.0003138187,0.00007638315,0.000005404774,0.00001345624,0.00001414827,0.00003419827,0.9987071,0.000009097601,0.000027075,0.0007512525],"study_design_scores_gemma":[0.00001301276,0.001056299,0.09273279,0.00004604598,0.000117178,0.0002819486,0.0002386708,0.001508827,0.8974569,0.0001039476,0.00642154,0.00002275141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9618444,0.006059112,0.009710897,0.0002630909,0.0001462269,0.0003209109,0.01795501,0.000159453,0.003540848],"genre_scores_gemma":[0.9497234,0.008407917,0.0151372,0.0005194687,0.00008693858,0.0006596656,0.01909521,0.0000608089,0.006309274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008559484,"threshold_uncertainty_score":0.002863467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379366396378122,"score_gpt":0.2664736394121449,"score_spread":0.2526799754483636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}