{"id":"W2517949748","doi":"10.1038/srep31727","title":"Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Adrenal Hormones and Disorders","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"U.S. Department of Defense; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Action Duchenne; National Institute of Neurological Disorders and Stroke; Parent Project Muscular Dystrophy; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Children's National Hospital; Muscular Dystrophy Association; Congressionally Directed Medical Research Programs; Foundation to Eradicate Duchenne; National Heart, Lung, and Blood Institute","keywords":"Pharmacodynamics; Medicine; Corticosteroid; Pharmacology; Drug; Hormone; Prednisolone; Internal medicine; Endocrinology; Bioinformatics; Pharmacokinetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000194434,0.0001312931,0.0002424921,0.0001260244,0.00009075878,0.00001541638,0.00004198504,0.00004064117,0.0001636591],"category_scores_gemma":[0.00003332157,0.00007576675,0.0002020725,0.000172146,0.0002332143,0.00007177282,0.00001681308,0.00001283537,0.00001078075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640338,"about_ca_system_score_gemma":0.0002338213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002094216,"about_ca_topic_score_gemma":0.0000147078,"domain_scores_codex":[0.9985995,0.000009082538,0.0004152393,0.0004592405,0.0002375608,0.0002793541],"domain_scores_gemma":[0.9989917,0.00002216149,0.0002412196,0.0004967637,0.0001075808,0.0001405838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003616053,0.0006732452,0.1515508,0.00008472869,0.0004611686,0.0001364314,0.0001255679,0.000004877124,0.5757536,0.00002066423,0.006855552,0.2639717],"study_design_scores_gemma":[0.01759998,0.005754401,0.266603,0.0005155451,0.001387714,0.002855899,0.0001380757,0.001069012,0.651972,0.002725835,0.04853208,0.0008464188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949581,0.001134006,0.0006295189,0.0004295432,0.001455726,0.001012928,0.00002419053,0.0000399483,0.0003160528],"genre_scores_gemma":[0.9954674,0.00006192006,0.000140205,0.00001158498,0.00006232077,0.0000451202,0.00006339014,0.00001757252,0.004130492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2631253,"threshold_uncertainty_score":0.3089678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331686757586059,"score_gpt":0.2854906350482804,"score_spread":0.2721737674724198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}