{"id":"W2517949748","doi":"10.1038/srep31727","title":"Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Adrenal Hormones and Disorders","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"U.S. Department of Defense; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Action Duchenne; National Institute of Neurological Disorders and Stroke; Parent Project Muscular Dystrophy; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Children's National Hospital; Muscular Dystrophy Association; Congressionally Directed Medical Research Programs; Foundation to Eradicate Duchenne; National Heart, Lung, and Blood Institute","keywords":"Pharmacodynamics; Medicine; Corticosteroid; Pharmacology; Drug; Hormone; Prednisolone; Internal medicine; Endocrinology; Bioinformatics; Pharmacokinetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001231038,0.0005736218,0.000429514,0.001364235,0.0001938823,0.0008371139,0.0002888886,0.0005193605,0.001439116],"category_scores_gemma":[0.002093999,0.0001456906,0.0003336899,0.001131049,0.0003006854,0.0002468268,0.000300918,0.0007834668,0.0004133192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427531,"about_ca_system_score_gemma":0.0004602668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009038532,"about_ca_topic_score_gemma":0.0009584808,"domain_scores_codex":[0.9991435,0.0002488389,0.0001008473,0.00009920185,0.0003519205,0.00005561659],"domain_scores_gemma":[0.9985228,0.0004895595,0.0006181638,0.00006675706,0.000209714,0.00009302267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001764424,0.0002523885,0.7365648,0.001090068,0.0003669421,0.001621272,0.0002712327,0.0008681986,0.09365526,0.000672494,0.005539609,0.1573332],"study_design_scores_gemma":[0.00006577806,0.001140136,0.9044322,0.0002797588,0.0003417366,0.007409637,0.0002198391,0.002093974,0.05409811,0.0006350114,0.0292409,0.00004288281],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7646634,0.1892754,0.01896302,0.003955657,0.0004967999,0.0003483912,0.005154138,0.0008202602,0.0163229],"genre_scores_gemma":[0.9613567,0.01758884,0.0156123,0.0009975627,0.0003574664,0.0001838834,0.00146937,0.00004646933,0.002387542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001439116,"threshold_uncertainty_score":0.006510437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331686757586059,"score_gpt":0.2854906350482804,"score_spread":0.2721737674724198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}