{"id":"W2518030659","doi":"10.1111/his.13063","title":"Analysis of papillary urothelial carcinomas of the bladder with grade heterogeneity: supportive evidence for an early role of <i><scp>CDKN</scp>2A</i> deletions in the <i><scp>FGFR</scp>3</i> pathway","year":2016,"lang":"en","type":"article","venue":"Histopathology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Health Sciences Centre; University Health Network; Sunnybrook Health Science Centre","funders":"","keywords":"CDKN2A; Biology; Cancer research; Immunohistochemistry; Fluorescence in situ hybridization; Pathology; Carcinoma; Carcinogenesis; In situ hybridization; Mutation; Cancer; Medicine; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005078242,0.0002808541,0.0008561825,0.0003121855,0.00009175319,0.000004948884,0.0004111573,0.0001743982,0.00000931104],"category_scores_gemma":[0.0003239091,0.0001457604,0.0004220881,0.0007892528,0.0006932736,0.0001218155,0.00006255345,0.0001545864,0.000001866136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009209434,"about_ca_system_score_gemma":0.0003739855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005860368,"about_ca_topic_score_gemma":0.001041308,"domain_scores_codex":[0.9975429,0.0004470449,0.0006606669,0.0004997827,0.0004303223,0.0004192507],"domain_scores_gemma":[0.9973137,0.0007661782,0.0005245736,0.0009909978,0.0003045033,0.0001000162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001488782,0.0006119569,0.7225524,0.00006719759,0.0002856931,0.00003243767,0.005550639,0.00001775952,0.2697246,0.0002459204,0.0001895134,0.0005730448],"study_design_scores_gemma":[0.002499758,0.003385196,0.851534,0.0001842689,0.00307328,0.00009058779,0.0009840077,0.00002067755,0.1362604,0.000257943,0.001648629,0.00006123055],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994969,0.002133319,0.0004302495,0.0001942619,0.00009503356,0.00106744,0.0005389053,0.00001695706,0.0005548222],"genre_scores_gemma":[0.9985619,0.0001319562,0.0002094566,0.0004551057,0.00006474704,0.0002505351,0.00002811176,0.00003778832,0.0002604222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1334642,"threshold_uncertainty_score":0.5943937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03746038239340448,"score_gpt":0.2866700539032492,"score_spread":0.2492096715098447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}