{"id":"W2518030659","doi":"10.1111/his.13063","title":"Analysis of papillary urothelial carcinomas of the bladder with grade heterogeneity: supportive evidence for an early role of <i><scp>CDKN</scp>2A</i> deletions in the <i><scp>FGFR</scp>3</i> pathway","year":2016,"lang":"en","type":"article","venue":"Histopathology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Health Sciences Centre; University Health Network; Sunnybrook Health Science Centre","funders":"","keywords":"CDKN2A; Biology; Cancer research; Immunohistochemistry; Fluorescence in situ hybridization; Pathology; Carcinoma; Carcinogenesis; In situ hybridization; Mutation; Cancer; Medicine; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004062504,0.0002205456,0.0002412409,0.001339403,0.0002814893,0.0004269585,0.000247606,0.0002587038,0.0009248384],"category_scores_gemma":[0.001349272,0.000202094,0.0002620209,0.0006060347,0.0003189697,0.0002396914,0.0004229183,0.0001329099,0.0002001006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002391673,"about_ca_system_score_gemma":0.0002129336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021571,"about_ca_topic_score_gemma":0.001534866,"domain_scores_codex":[0.9995807,0.00007694266,0.00007374128,0.00008935997,0.0001101603,0.00006913816],"domain_scores_gemma":[0.9988166,0.0003649528,0.0003252787,0.0001607107,0.0001743024,0.0001580919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004534114,0.00002313899,0.9057909,0.00009332922,0.00006881134,0.001386556,0.0001860151,0.00007832568,0.08627791,0.00004552317,0.00003743592,0.005558611],"study_design_scores_gemma":[0.00001116536,0.0001969743,0.9725242,0.000008567622,0.0000706901,0.01080243,0.000155542,0.0003427162,0.01543356,0.00005813063,0.0003894773,0.000006492035],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989717,0.0001912224,0.000487306,0.000004181881,7.795854e-7,0.000009832067,0.00006211871,0.000008032133,0.0002646715],"genre_scores_gemma":[0.9994798,0.0000496424,0.0002776298,0.000002844302,0.000001333007,0.000005341017,0.0001330673,0.000002061806,0.00004826986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339403,"threshold_uncertainty_score":0.003093839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03746038239340448,"score_gpt":0.2866700539032492,"score_spread":0.2492096715098447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}