{"id":"W2518102938","doi":"10.1182/blood.v122.21.1950.1950","title":"Phase 1b/2a Open-Label, Multiple-Dose, Dose-Escalation Study To Evaluate The Safety and Tolerability Of Intravenous Infusion Of SNS01-T In Patients With Relapsed Or Refractory Multiple Myeloma, Mantle Cell Lymphoma, Or Diffuse Large B Cell Lymphoma","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Tolerability; Apoptosis; Cancer research; Medicine; Mantle cell lymphoma; Multiple myeloma; Lymphoma; Biology; Pharmacology; Immunology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000375415,0.000233513,0.0003674008,0.00006054343,0.0001229696,0.00002627308,0.0003680657,0.0001006704,0.00001674306],"category_scores_gemma":[0.000159992,0.0001439166,0.00002706899,0.0002457616,0.00007755247,0.00002407933,0.0003877414,0.00005594635,0.000005194939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001682454,"about_ca_system_score_gemma":0.0001248922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004536541,"about_ca_topic_score_gemma":0.0006016208,"domain_scores_codex":[0.9982395,0.0002173389,0.0005756202,0.0004703622,0.0002297599,0.0002674117],"domain_scores_gemma":[0.9985943,0.00009497158,0.0002491826,0.0007493497,0.0002017093,0.0001104685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008573665,0.254044,0.157245,0.0001146503,0.00009486905,0.00000220684,0.002006816,0.000009784141,0.5462782,0.000002912589,0.00009057766,0.03153732],"study_design_scores_gemma":[0.1649639,0.004678586,0.7019889,0.0000251523,0.0001220555,0.000001174815,0.0004487146,0.0002928629,0.1266139,0.000004068245,0.0005992551,0.0002613792],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964209,0.0001138468,0.00009347755,0.00001958515,0.0000326749,0.00295143,0.0002934982,0.000007375301,0.00006726545],"genre_scores_gemma":[0.9987242,0.00005884371,0.0005839046,0.00005512176,0.00002242103,0.0001845212,0.0002056108,0.0000250817,0.0001402974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.544744,"threshold_uncertainty_score":0.5868748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01285886823048338,"score_gpt":0.2636663626480961,"score_spread":0.2508074944176127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}