{"id":"W2518102938","doi":"10.1182/blood.v122.21.1950.1950","title":"Phase 1b/2a Open-Label, Multiple-Dose, Dose-Escalation Study To Evaluate The Safety and Tolerability Of Intravenous Infusion Of SNS01-T In Patients With Relapsed Or Refractory Multiple Myeloma, Mantle Cell Lymphoma, Or Diffuse Large B Cell Lymphoma","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Tolerability; Apoptosis; Cancer research; Medicine; Mantle cell lymphoma; Multiple myeloma; Lymphoma; Biology; Pharmacology; Immunology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001068188,0.001607014,0.00233153,0.0004061437,0.0004221838,0.0008908292,0.0007051572,0.001115937,0.004168587],"category_scores_gemma":[0.0005040588,0.0005518261,0.0009581553,0.0004133439,0.0008370545,0.0008088617,0.00028513,0.002541353,0.0008695406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001055053,"about_ca_system_score_gemma":0.001180934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006375952,"about_ca_topic_score_gemma":0.001486165,"domain_scores_codex":[0.9996852,0.0001252314,0.0000118148,0.00007303292,0.00003638362,0.00006848558],"domain_scores_gemma":[0.9996578,0.00003352408,0.00006031009,0.00004960069,0.00003179834,0.000167016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5554675,0.1528214,0.00407705,0.001113012,0.001148598,0.0003132831,0.0003834041,0.003880755,0.1750636,0.0006263376,0.004731345,0.1003736],"study_design_scores_gemma":[0.2647414,0.7093359,0.005992191,0.00003181077,0.0003119795,0.0002297558,0.00006803586,0.002398185,0.01109686,0.0003195686,0.005440555,0.00003381605],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905322,0.001237381,0.001550525,0.0002523841,0.0001694827,0.003675241,0.001019841,0.0001392268,0.001423824],"genre_scores_gemma":[0.9780502,0.001214824,0.003981291,0.000671951,0.0001441578,0.007161479,0.002339266,0.00008045465,0.006356432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004168587,"threshold_uncertainty_score":0.01394534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01285886823048338,"score_gpt":0.2636663626480961,"score_spread":0.2508074944176127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}