{"id":"W2518284609","doi":"10.1073/pnas.1610253113","title":"Network pharmacology of JAK inhibitors","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Pfizer","keywords":"Epigenomics; Biology; Immunology; Population; Bioinformatics; Computational biology; Medicine; Gene; Genetics; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006085797,0.00004992669,0.000135751,0.00009972763,0.00006600386,0.000002151459,0.0002076123,0.00004431591,0.0001021527],"category_scores_gemma":[0.0002892331,0.00002482234,0.00007560876,0.0004280765,0.0006064241,0.0001558396,0.00005905635,0.00008041567,0.000001419477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000207238,"about_ca_system_score_gemma":0.00003853382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002712514,"about_ca_topic_score_gemma":1.166247e-8,"domain_scores_codex":[0.9989815,0.000003055474,0.0002792988,0.0001148427,0.0005222063,0.00009905189],"domain_scores_gemma":[0.9991813,0.0001338537,0.000344596,0.000003919775,0.0003103496,0.00002599921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003084738,0.00003943243,0.007924143,0.00002706279,0.00001567087,2.521031e-9,0.00003713036,0.00001334801,0.966756,0.01145907,0.01329529,0.0004019723],"study_design_scores_gemma":[0.0002850069,0.0001160497,0.02152288,0.0002629702,0.00002469528,0.00001123528,0.00003481871,0.00006651218,0.9666755,0.00875253,0.00221663,0.00003120154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790177,0.00008417258,0.000001421836,0.01116358,0.00008427318,0.0001198127,0.000008739059,0.000007091647,0.009513264],"genre_scores_gemma":[0.998541,0.00002189832,0.0004978636,0.0003681175,0.0003401218,0.000004038293,2.892764e-8,0.000002342996,0.0002245692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01952337,"threshold_uncertainty_score":0.2234395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05452870080677494,"score_gpt":0.3432860872209051,"score_spread":0.2887573864141302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}