{"id":"W2518320770","doi":"10.2196/resprot.6024","title":"A Cross-Sectional Comparison of Druggable Mutations in Primary Tumors, Metastatic Tissue, Circulating Tumor Cells, and Cell-Free Circulating DNA in Patients with Metastatic Breast Cancer: The MIRROR Study Protocol","year":2016,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Druggability; Metastatic breast cancer; Medicine; Circulating tumor cell; Breast cancer; Oncology; Cancer; Internal medicine; Pathology; Metastasis; Biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00294822,0.0005719834,0.0005955104,0.00052203,0.0005923533,0.0004849461,0.0005146357,0.0005689722,0.002162],"category_scores_gemma":[0.003741695,0.0004642527,0.0005233285,0.0004280405,0.0004434885,0.0004812133,0.0006689194,0.0003489599,0.0006848694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006006815,"about_ca_system_score_gemma":0.0009075601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000855347,"about_ca_topic_score_gemma":0.001012428,"domain_scores_codex":[0.9986184,0.0006112974,0.0001793697,0.0003288026,0.0001565446,0.0001055409],"domain_scores_gemma":[0.9979944,0.0003795971,0.0005418758,0.0003962781,0.0004106582,0.0002771146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03483875,0.002987149,0.9419849,0.0001522813,0.0003022722,0.0002240627,0.0004381457,0.0002758874,0.009206084,0.000186521,0.0008237489,0.008580211],"study_design_scores_gemma":[0.00243509,0.03083415,0.9592634,0.00002347912,0.0002297256,0.0006789265,0.0003323877,0.0005807396,0.002210955,0.00008272639,0.003301417,0.00002695758],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9922528,0.0001221961,0.001003199,0.00003583243,0.00001187332,0.004166787,0.001388814,0.00001279932,0.001005809],"genre_scores_gemma":[0.9815263,0.00008230072,0.003149977,0.0001479037,0.00003067187,0.0110269,0.00335095,0.00001389673,0.0006711397],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.00294822,"threshold_uncertainty_score":0.01559186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06605293329006323,"score_gpt":0.4438038994826555,"score_spread":0.3777509661925923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}