{"id":"W2518416841","doi":"10.14814/phy2.12853","title":"Astrocyte-mediated regulation of multidrug resistance<scp>P</scp>-glycoprotein in fetal and neonatal brain endothelial cells: age-dependent effects","year":2016,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Astrocyte; Fetus; P-glycoprotein; Biology; Endogeny; Cell biology; Endocrinology; Internal medicine; Central nervous system; Medicine; Multiple drug resistance; Pregnancy; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004197503,0.0002589009,0.000644752,0.0001059437,0.00004474851,0.000007495646,0.00006335166,0.0002069376,0.0000249661],"category_scores_gemma":[0.001077782,0.0001539458,0.0001452339,0.0001524555,0.0002213185,0.00009311104,0.00004470067,0.0001901057,0.000007030209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006527331,"about_ca_system_score_gemma":0.00005792302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002788236,"about_ca_topic_score_gemma":0.00006764804,"domain_scores_codex":[0.9977794,0.00009875605,0.0006718457,0.0005951701,0.0004633208,0.0003914555],"domain_scores_gemma":[0.9985039,0.0004936314,0.0004171599,0.0003344609,0.00006578243,0.000185079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003703521,0.0001723062,0.001795806,0.0002100548,0.00002707554,0.002163898,0.0001219502,0.000004978187,0.9915032,0.00008270091,0.0001067244,0.003440948],"study_design_scores_gemma":[0.002844567,0.0003761559,0.2240533,0.0006421349,0.00003552927,0.00005261206,0.00006063844,0.00002310529,0.7677619,0.002893419,0.001135002,0.0001216585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968833,0.000274369,0.00120124,0.0001246032,0.0001997083,0.0008164765,0.00002331735,0.00008082855,0.0003961024],"genre_scores_gemma":[0.9956679,0.00007525738,0.001344735,0.00005932357,0.0001109764,0.00006216526,0.0000512397,0.00002483955,0.002603567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2237413,"threshold_uncertainty_score":0.6277727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008627310296034224,"score_gpt":0.225501128734711,"score_spread":0.2168738184386767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}