{"id":"W2518458425","doi":"10.1038/ncomms12639","title":"MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Melanoma Research Alliance","keywords":"Insulin resistance; Insulin receptor; Ubiquitin ligase; Insulin; Downregulation and upregulation; Insulin receptor substrate; Endocrinology; Internal medicine; Biology; Ubiquitin; IRS2; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005413508,0.00017488,0.0001693477,0.00002552113,0.0002393121,0.00002650515,0.0005752036,0.0004856601,0.00003782753],"category_scores_gemma":[0.0003746184,0.0001390354,0.00009267514,0.0001145736,0.0001824178,0.00000852007,0.0003966525,0.0004150319,0.00006866129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000279954,"about_ca_system_score_gemma":0.00008287175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001403415,"about_ca_topic_score_gemma":0.00007574962,"domain_scores_codex":[0.9986565,0.0004443973,0.0002240994,0.000301137,0.0001244579,0.0002494177],"domain_scores_gemma":[0.9977688,0.0002536812,0.0001296697,0.001538865,0.000208578,0.0001004469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004779806,0.000093572,0.0004821406,0.000005860698,0.00002588465,2.762502e-7,0.00003143246,0.000003598481,0.9857525,0.0002983466,0.009698094,0.003560507],"study_design_scores_gemma":[0.0007031118,0.00005244375,0.000586608,0.00002454693,0.000009167299,0.000003164151,0.00001745875,0.00005236025,0.730891,0.00008730423,0.2673856,0.0001872324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9413857,0.03815907,0.002350395,0.01109521,0.000210147,0.000621315,0.001504114,0.00009261606,0.004581389],"genre_scores_gemma":[0.985998,0.003012039,0.008627712,0.0005158873,0.00009140741,0.00002091528,0.0003450789,0.00002994811,0.001358975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2576875,"threshold_uncertainty_score":0.56697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632626205883201,"score_gpt":0.262262566924209,"score_spread":0.245936304865377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}