{"id":"W2518458425","doi":"10.1038/ncomms12639","title":"MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Melanoma Research Alliance","keywords":"Insulin resistance; Insulin receptor; Ubiquitin ligase; Insulin; Downregulation and upregulation; Insulin receptor substrate; Endocrinology; Internal medicine; Biology; Ubiquitin; IRS2; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001794929,0.0003990331,0.0002872901,0.0002736225,0.0002122044,0.0007214332,0.0003475568,0.0003067036,0.001707273],"category_scores_gemma":[0.0002446831,0.0001915926,0.0003171784,0.000244257,0.00027808,0.0003120563,0.000360623,0.0005625723,0.0009329271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005540003,"about_ca_system_score_gemma":0.0001829047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003478049,"about_ca_topic_score_gemma":0.0004592352,"domain_scores_codex":[0.9998417,0.00002030159,0.00001303023,0.00004309066,0.00004098437,0.00004092211],"domain_scores_gemma":[0.999827,0.00001967567,0.00007098311,0.00001801684,0.00002155491,0.00004270584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003041365,0.00001619247,0.0009323785,0.00006751576,0.00001230992,0.00008830272,0.00001575926,0.0001399158,0.9930208,0.0004325328,0.0002108294,0.004759356],"study_design_scores_gemma":[0.00004672645,0.0002195316,0.01662502,0.00001829698,0.00006831063,0.0005825261,0.00005289042,0.002555131,0.964204,0.0004408883,0.01516998,0.00001676743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758203,0.007707908,0.009189095,0.0007509892,0.0001049942,0.00003416909,0.001269429,0.0004953766,0.004627674],"genre_scores_gemma":[0.9890106,0.002906966,0.003462383,0.0001239553,0.00002580645,0.00002325669,0.0007888881,0.00007264566,0.003585455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001707273,"threshold_uncertainty_score":0.005711436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632626205883201,"score_gpt":0.262262566924209,"score_spread":0.245936304865377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}