{"id":"W2518534345","doi":"10.1016/j.str.2016.07.014","title":"Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification","year":2016,"lang":"en","type":"article","venue":"Structure","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Engineering and Physical Sciences Research Council; National Science Foundation; National Institutes of Health; National Cancer Institute; National Institute of General Medical Sciences; Sidney Kimmel Center for Prostate and Urologic Cancers","keywords":"Ankyrin repeat; Ankyrin; Poly ADP ribose polymerase; Chemistry; Computational biology; Biochemistry; Cell biology; Genetics; Biology; DNA; Gene; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002963999,0.0003508697,0.00032105,0.000256474,0.0002859148,0.0005597619,0.0006498484,0.000488035,0.002742778],"category_scores_gemma":[0.0003401189,0.0002270583,0.0003099639,0.0002106602,0.0002870866,0.0006368416,0.000846554,0.000746878,0.001392314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005979577,"about_ca_system_score_gemma":0.0002187308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003592889,"about_ca_topic_score_gemma":0.0004404425,"domain_scores_codex":[0.9997856,0.00004584839,0.00001419331,0.00005446169,0.00005726596,0.00004275261],"domain_scores_gemma":[0.999836,0.00001728457,0.00006911712,0.00002284472,0.00001806132,0.0000366771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003018554,0.00002229884,0.001216315,0.00004752809,0.00004289934,0.0004311551,0.00006377454,0.0007207022,0.9868896,0.00188078,0.0005256297,0.007857407],"study_design_scores_gemma":[0.00008212429,0.0004857689,0.01447138,0.0000211869,0.00007067205,0.002570227,0.0001381901,0.007206786,0.9493048,0.003435553,0.02215855,0.00005480568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9546372,0.003700606,0.03561332,0.0006145296,0.0001281658,0.00005344594,0.0004364605,0.000535408,0.004280976],"genre_scores_gemma":[0.9877708,0.0004358585,0.007035665,0.0001316336,0.00002388176,0.00002061898,0.0002815163,0.00003750177,0.004262493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002742778,"threshold_uncertainty_score":0.009175479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03984034997612973,"score_gpt":0.2986361798608527,"score_spread":0.2587958298847229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}