{"id":"W2518545320","doi":"10.15252/emmm.201606540","title":"Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease","year":2016,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":313,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Magnus Bergvalls Stiftelse; Greta och Johan Kocks stiftelser; Göteborgs Universitet; Fujirebio Europe; Servier; Knut och Alice Wallenbergs Stiftelse; Hjärnfonden; Vetenskapsrådet; Eisai; Elan; Lunds Universitet; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; European Research Council; Northern California Institute for Research and Education; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; Torsten Söderbergs Stiftelse; Synarc; IXICO; Takeda Pharmaceutical Company; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Merck; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Johnson and Johnson; Meso Scale Diagnostics","keywords":"Neurogranin; Cerebrospinal fluid; Pathology; Alzheimer's disease; Medicine; Glymphatic system; Neurodegeneration; Disease; Chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001678718,0.0005092716,0.0005795952,0.002212711,0.0003950058,0.0008905631,0.0002634733,0.0004001025,0.0003405822],"category_scores_gemma":[0.003660559,0.0003097311,0.000261205,0.001094106,0.0005444628,0.0005525579,0.0005241903,0.0003303356,0.0001518127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005137096,"about_ca_system_score_gemma":0.0003995752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003909251,"about_ca_topic_score_gemma":0.004747294,"domain_scores_codex":[0.9995153,0.0001963077,0.00007194049,0.00006107152,0.0001156095,0.00003975872],"domain_scores_gemma":[0.9990202,0.0003278995,0.0003380511,0.0000540003,0.0001349163,0.0001248467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009410377,0.00007670593,0.9838414,0.00007141186,0.0002166315,0.0003388749,0.0001937746,0.0003300514,0.001238856,0.00005550921,0.0001801614,0.01251548],"study_design_scores_gemma":[0.00004033874,0.0001839982,0.9961339,0.00003932208,0.0001327,0.0008407428,0.0002061055,0.001120169,0.000532874,0.0003800511,0.0003775685,0.0000121168],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951681,0.004294444,0.00010585,0.0000753501,0.00001240537,0.000005227476,0.00004822788,0.000003718108,0.0002866427],"genre_scores_gemma":[0.9988801,0.0007405305,0.0002028797,0.0000176278,0.00002054856,0.000004152044,0.0000517726,8.262096e-7,0.00008138948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003909251,"threshold_uncertainty_score":0.008878052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356560389826225,"score_gpt":0.2948791274390314,"score_spread":0.2813135235407692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}