{"id":"W2518545320","doi":"10.15252/emmm.201606540","title":"Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease","year":2016,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":313,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Magnus Bergvalls Stiftelse; Greta och Johan Kocks stiftelser; Göteborgs Universitet; Fujirebio Europe; Servier; Knut och Alice Wallenbergs Stiftelse; Hjärnfonden; Vetenskapsrådet; Eisai; Elan; Lunds Universitet; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; European Research Council; Northern California Institute for Research and Education; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; Torsten Söderbergs Stiftelse; Synarc; IXICO; Takeda Pharmaceutical Company; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Merck; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Johnson and Johnson; Meso Scale Diagnostics","keywords":"Neurogranin; Cerebrospinal fluid; Pathology; Alzheimer's disease; Medicine; Glymphatic system; Neurodegeneration; Disease; Chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003004292,0.0002343822,0.0003409944,0.0002742888,0.00004818682,0.00001286341,0.000104789,0.0000461098,0.0006230821],"category_scores_gemma":[0.0002699016,0.0001448212,0.00006575046,0.0002883956,0.0002510295,0.00007261356,0.0001057145,0.0001658424,0.00005310561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003196289,"about_ca_system_score_gemma":0.00008492543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002740382,"about_ca_topic_score_gemma":0.000002487107,"domain_scores_codex":[0.9978545,0.0001300544,0.0003233994,0.0005060717,0.0007018981,0.0004840711],"domain_scores_gemma":[0.9988123,0.00004880943,0.0000484296,0.0003485633,0.0001072126,0.0006347539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001168028,0.000520162,0.2621085,0.0001122614,0.0001817941,0.007172086,0.0001612976,2.056217e-7,0.6555455,0.001134114,0.003610311,0.06828582],"study_design_scores_gemma":[0.008570511,0.002289958,0.9505548,0.0007742113,0.0003902893,0.000118365,0.00006359128,0.00003696035,0.02093446,0.0003750157,0.01566898,0.0002228693],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9415233,0.005191814,0.0005188137,0.04799443,0.000148355,0.0008311674,0.000003835586,0.00005372963,0.003734556],"genre_scores_gemma":[0.9949953,0.0004805925,0.00005794883,0.003832174,0.0001454554,0.00007144697,0.00001442457,0.00003642171,0.0003662317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6884463,"threshold_uncertainty_score":0.6822312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356560389826225,"score_gpt":0.2948791274390314,"score_spread":0.2813135235407692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}